Results 41 to 50 of about 2,947,588 (303)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The Case for Countercyclical Fiscal Capacity [PDF]
Journal of Public Administration Research and Theory, 2006 A growing literature has sought to demonstrate when and how government capacity links to performance. This article examines those questions in the area of financial management. A basic challenge for state governments is to maintain budgetary stability and program predictability in face of economic downturns.
Y. Hou, D. P. Moynihan
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Köz-gazdaságThis study conducts a structured literature review examining the role of fiscal institutions in promoting fiscal discipline, managing public debt, and supporting economic stability in Sub-Saharan Africa. By synthesising theoretical and empirical studies
Esau Washipobe Wesa, Marianna Sávai
doaj +1 more source
Journal of Economic Development, Environment and People, 2018 This research aims to analyse the degree of fiscal dependence of local government upon the central government in the regency of Mimika, one of Indonesia’s eastern regencies. The ratio of fiscal decentralization is used to calculate the local government’s
Elsyan Rienette MARLISSA +1 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
, 2019 This chapter examines the notion of fiscal capacity – as a centralized budget, funded by own resources, to be spent in pursuance of strategic priorities – in the European Union (EU). The chapter explains that the EU’s Economic & Monetary Union (EMU) launched by the Treaty of Maastricht was asymmetry, as it lacked a fiscal capacity. The chapter analyses
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Options for a Euro-area fiscal capacity. Bruegel Policy Brief 2013/01, January 2013 [PDF]
, 2013 Europe has responded to the crisis with strengthened budgetary and macroeconomic surveillance, the creation of the European Stability Mechanism, liquidity provisioning by resilient economies and the European Central Bank and a process towards a banking ...
Vihriälä , Erkki +2 more
core
Fiscal capacity and public health expenditure in Zimbabwe
Cogent Economics & Finance, 2023 Public healthcare financing is important for achieving one of the 2030 Sustainable Development Goals (SDGs), the goal of healthy living and well-being (SDG3).
Tamisai Chipunza, Senia Nhamo
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source