Results 31 to 40 of about 2,004,826 (306)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
The Impact of “Troubled Times” on Economic and Financial Legislation in Romania
CECCAR Business ReviewJoint actions of decision-making factors both at national level and beyond domestic borders in view of counteracting the consequences of relatively recent unfavourable events have also led to the emergence of various legislative actions, including in the
Claudia-Florina BOTAR
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Discuții și propuneri de lege ferenda cu privire la competența organelor fiscale
Revista Transilvană de Ştiinţe Administrative, 2009 The enactment of the Code of Fiscal Procedure in 2003 represents a major step toward the unification of the Romanian fiscal legislation. Unfortunately, the Romanian Fiscal Law continues to be scattered by the enactment of a plethora of legislative acts ...
Nadia Cerasela DARIESCU, Cosmin DARIESCU
doaj
Tax Treatment of Income from Intellectual Property Rights
CECCAR Business ReviewThe article presents a series of theoretical and practical issues regarding the declaration and payment obligations regarding the taxation of income from intellectual property rights.
Lucian CERNUȘCA
doaj +1 more source
About inevitability of budgetary code receiving for fiscal politics
, 2021 Since the end of 90s till today when all the elements confirming Georgian State System have practically been established, budget system and policy remains as the most difficult Georgian macroeconomics challenge and even still half-and-half unsolved problem. One side of the fiscal policy is quite crucially formulated and administrative Tax Code, and the
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Revista Transilvană de Ştiinţe Administrative, 2004 This paper is trying to present „the newer Romanian fiscal framework”. The fiscal code was expected to solve some fundamental issues such as: unification and armonization of Romanian fiscal legislation with the European Union’s regulations; the ...
Adrian Mihai INCEU, Dan Tudor LAZĂR
doaj
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source