Results 41 to 50 of about 936,517 (357)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Remote work and long-term sickness absence due to mental disorder trends among Japanese workers pre/post COVID-19.

PLoS ONE
AimsThe aim of this study was to ascertain whether there has been an increase in the number of workers with long-term sickness absence due to mental disorders (LTSA-MD) and determine the impact of remote work on new LTSA-MD cases.MethodsA web-based ...
Yasuhiko Deguchi, Shinichi Iwasaki, Yuki Uesaka, Yutaro Okawa, Shohei Okura, Kunio Maekubo, Ayaka Matsunaga, Yuki Kageyama, Koki Inoue   +8 more
doaj   +1 more source

Using Mediation to Address Sexual Harassment Claims in the Work Place [PDF]

, 2005
Sexual harassment continues to be a serious problem in the work place in terms of the number of claims being filed, the new types of claims filed, and the cost to the employer.
Bedikian, Mary, Pace, Diana, Swift, Maris Stella   +2 more
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Analisis Tingkat Ketergantungan Fiskal dan Hubungannya dengan Pertumbuhan Ekonomi Kota Jambi

Jurnal Perspektif Pembiayaan dan Pembangunan Daerah, 2015
This study aimed to quantify the fiscal needs in the city jambi and analyze the relationship between the level of fiscal dependency of between the level of fiscal dependency of economic growth in the city of Jambi and see how big the city’s fiscal ...
Dito Wijaya, Haryadi Haryadi, Zulgani Zulgani   +2 more
doaj  

Rules for the Transition from the Income Taxation System of Micro-Enterprises to the Profit Tax

CECCAR Business Review
As a result of the adoption of Law No. 296/2023 regarding some fiscal-budgetary measures to ensure Romania’s long-term financial sustainability and Government Emergency Ordinance No.
Diana-Gabriela POHAȚĂ
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Howard Hughes Medical Institute 2013 Year in Review [PDF]

, 2014
The Howard Hughes Medical Institute is the nation's largest private supporter of academic biomedical research. As a medical research organization, the Institute spends at least 3.5 percent of its endowment each year on research activities and related ...

core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source