Results 141 to 150 of about 1,483,240 (277)

Effects of dietary inclusion of crude or hydrolyzed Arthrospira platensis on intestinal microbiota in gilthead seabream (Sparus aurata) fry

Discover Animals
Fish feed has traditionally relied on fishmeal and fish oil, but the industry is seeking sustainable alternatives, such as microalgae and cyanobacteria.
Juan Manuel Peralta-Sánchez, Miguel Rabelo-Ruiz, Antonio Manuel Martín-Platero, Marta Arizcun, Alba Galafat, Francisco Javier Alarcón-López, Alberto Baños, Claudia Teso Pérez, Manuel Martínez-Bueno   +8 more
doaj   +1 more source

High Cell Density Cultivation of HEK293 Cells Using a 2L Membrane‐Stirred Bioreactor

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The use of perfusion systems for the continuous cultivation of animal cells at high cell density (HCD) for the production of recombinant proteins, viruses, and viral vectors has many advantages. Besides an enhancement of volumetric productivity and high cell viability, the product quality can be improved through a steady‐state environment ...
Lennart Jacobtorweihe, Yasemin van Heuvel, Kathrina Scheiermann, Patrick Bongartz, Yvonne Genzel, Udo Reichl   +5 more
wiley   +1 more source

Model‐Driven Monitoring and Parameter‐Based Development of an Escherichia coli Fed‐Batch Process for Production of a Fab Antibody Fragment Across Scales

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Maintaining consistent cellular physiology during bioprocess scale‐up or scale‐down is key to developing robust processes. However, the reliability of scale‐down bioreactor systems remains debated. Although the calibration of physiological parameters in mechanistic models across scales has been proposed as a scale‐down strategy, few studies ...
Fabian Schröder‐Kleeberg, Lucas Kaspersetz, Markus Zoellkau, Markus Glaser, Markus Brunner, Christian Bosch, Annina Kemmer, M. Nicolas Cruz Bournazou, Peter Neubauer   +8 more
wiley   +1 more source

Reduced fish diversity despite increased fish biomass in a Gulf of California Marine Protected Area. [PDF]

PeerJ, 2020
Ramírez-Ortiz G, Reyes-Bonilla H, Balart EF, Olivier D, Huato-Soberanis L, Micheli F, Edgar GJ.   +6 more
europepmc   +1 more source

Automated Data‐Efficient Symbolic Regression for Interpretable Bioprocess Model Development

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Bioprocessing is central to the sustainable manufacture of pharmaceuticals, food products, and renewable chemicals. Consequently, developing high‐fidelity kinetic models to facilitate accurate process prediction, optimisation, and scale‐up is a top research priority.
Luca Riezzo, Alexander Rogers, Harry Kay, Dongda Zhang   +3 more
wiley   +1 more source

Predicting the effects of eutrophication mitigation on predatory fish biomass and the value of recreational fisheries. [PDF]

Ambio, 2020
Sundblad G, Bergström L, Söderqvist T, Bergström U.   +3 more
europepmc   +1 more source

Scalable Separation and Purification of M13‐Bacteriophage‐Derived Particles Containing Artificial Single‐Stranded DNA Produced by Escherichia coli

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Single‐stranded DNA (ssDNA) solutions are promising innovations shaping the future of genetic research and medical therapies. In principle, biotechnological mass production of ssDNA can be achieved using Escherichia coli in a high‐cell density fed‐batch process by secreting phagemid particles derived from the filamentous M13 bacteriophages ...
Nathalie Hafner, Wiebke Winkler, Maximilian N. Honemann, Hendrik Dietz, Dirk Weuster‐Botz   +4 more
wiley   +1 more source

A General Workflow for Tangential Flow Filtration Perfusion Scale‐Up

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Tangential flow filtration (TFF) perfusion using hollow‐fiber modules offers substantial advantages over other mammalian cell retention technologies. Recently, increased awareness of Starling flow has helped to enhance filtration performance to similar, or even higher levels compared to alternative technologies.
Patrick Romann, Ken Lee, Venkatesh Natarajan, Daniel Ley, Claes Nymand Nilsson, David Garcia‐Munzer, Dominik Schieman, Mahbod Hajighasemi, Alex Zaytsev, Jason Friedman, Loic Chappuis, Tobias Habicher, Colin Jaques, Alex Cohen, Matthew Gagnon, Edward Chan, Daniel J. Karst, Philip Giller, Antony Sibilia, Andrew L. Zydney, Thomas K. Villiger   +20 more
wiley   +1 more source

Combinatorial Metabolic Engineering of Alkane Biosynthesis in the Osmotolerant Yeast Debaryomyces hansenii CBS 767

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Debaryomyces hansenii is a yeast with diverse potential applications like producing oleochemicals from biomass. Yet, combinatorial metabolic engineering in D. hansenii is limited because, like many nonconventional organisms, key genomic data and genetic elements are missing. Here, we report phenotypic characterization, genomic integration loci,
Zekun Li, Nilesh Kumar Sharma, Sarah Weintraub, Eric Young   +3 more
wiley   +1 more source

Reducing Cooling Costs for Sustainable Food Biomanufacturing With Thermotolerant Cupriavidus necator H16 Mutant

Biotechnology and Bioengineering, EarlyView.
With a thermotolerant C. necator mutant the SCP production costs can be decreased by $0.98/kg. ABSTRACT Autotrophic CO2 conversion to Single Cell Protein (SCP) using H2 and O2 is gaining commercial traction for food and feed production. Cupriavidus necator H16 is a key chassis organism for this “knallgas” fermentation, but industrial operation is ...
Lars Puiman, James Kemp Heffernan, Esteban Marcellin   +2 more
wiley   +1 more source