Results 101 to 110 of about 1,124,634 (310)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Current state for stocks and fishery of saffron cod Eleginus gracilis (Tilesius, 1810) in the western Bering Sea

open access: yesИзвестия ТИНРО
State of stocks and fishery and some general features of biology are considered for saffron cod in the Bering Sea on results of bottom trawl surveys and commercial fishery statistics in 2000–2023. In 2023, the stock in the southwestern part of the sea is
O. V. Novikova, L. A. Chernoivanova
doaj   +1 more source

Winter and summer differences in probability of fish encounter (spatial overlap) with MHK devices

open access: yesInternational Marine Energy Journal, 2018
The likelihood of fish encountering an MHK device, and therefore the risk posed to fish, depends largely on the natural distribution of fish at tidal energy development sites.
H. Viehman, T. Boucher, A. Redden
doaj   +1 more source

Prevalence, intensity, and effect of a nematode (Philometra saltatrix) in the ovaries of bluefish (Pomatomus saltatrix) [PDF]

open access: yes, 2006
Examination of 203 adult bluefish (Pomatomus saltatrix) from Long Island, New York, in 2002 and 2003 and 66 from the Outer Banks, North Carolina, in 2003 revealed the presence of dracunculoid nematodes (Philometra saltatrix) in the ovaries of female ...
Clarke, Lora M.   +2 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

New records of Endangered Slender Walking Catfish, Clarias pseudonieuhofii Sudarto, Teugels & Pouyaud, 2004 (Siluriformes, Clariidae) from Central Mahakam River, East Kalimantan, Indonesia [PDF]

open access: yesCheck List
Clariidae, commonly referred as air-breathing or walking catfishes, are a family of catfish distributed in Africa, Asia Minor, the Indian subcontinent, and Southeast Asia. Some species are highly valuable as food fish.
Rudhy Gustiano   +5 more
doaj   +3 more sources

Water quality and nutrient dynamics - Lake Victoria, Kenya [PDF]

open access: yes, 1999
Limnological studies in Lake Victoria (Kenyan portion) have been sporadic. Water quality and nutrient dynamics studies are being undertaken in fifteen sampling sites that have been divided into four ecological zones namely: Nyanza Gulf, Rusinga Channel ...
Kenyanya, M.M.
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

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