Results 81 to 90 of about 215,215 (259)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
International Journal of Nanomedicine, 2011 Yan Wang1, Chen-lu Zhang2, Qun Zhang1, Ping Li1,31School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China; 2College of Life Sciences, Nanjing Agricultural University, Nanjing, People’s Republic ...
Li P, Wang Y, Zhang CL, Zhang Q
doaj
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Application of the circular economy to fish scale waste
Sustainable Chemistry for the EnvironmentFish is a prominent protein source due to its affordability and nutritional safety. Although many people consume fish, they might not know how much fish scale debris is produced by the food and aquaculture sectors.
M. Manjudevi +3 more
doaj +1 more source
Knowledge and Management of Aquatic Ecosystems, 2017 Coastal streams provide important habitat for many diadromous fish species, which migrate between freshwater and the sea during their life cycle. However, coastal systems are poorly studied in comparison to large, continental river systems.
Mitsuo Yoshito
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Journal of Freshwater Ecology, 2017 Land cover change for agricultural expansion exerts strong pressures on tropical streams. We examined the relative contributions of catchment land cover, local environmental features, and spatial patterns on stream fish communities (n = 43).
Camilo A. Roa-Fuentes, Lilian Casatti
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Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source