Results 41 to 50 of about 72,108 (314)
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Ribogospodarsʹka Nauka Ukraïni, 2016 Purpose. The determination and analysis of main biological characteristics of silver bream from the point of view of the formation and exploitation of its commercial stock in the Kyiv reservoir. Methodology. The work is based the results of monitoring
I. Zakharchenko +2 more
doaj +1 more source
Seafood substitutions obscure patterns of mercury contamination in Patagonian toothfish (Dissostichus eleginoides) or "Chilean sea bass". [PDF]
PLoS ONE, 2014 Seafood mislabeling distorts the true abundance of fish in the sea, defrauds consumers, and can also cause unwanted exposure to harmful pollutants.
Peter B Marko +2 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Reversal of Fish Stock Decline in the Northeast Atlantic [PDF]
Current Biology, 2013 Analyses of global fish stocks paint a mixed picture of success, with some holding fishery management responsible for the poor status of many stocks [1-3] or predicting widespread collapse [1, 4]. Some suggest a stable [5] or improving situation [6] in certain jurisdictions.
Fernandes, Paul G., Cook, Robin
openaire +4 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Study of fisheries from riverine Danube Delta: Gorgova – Uzlina and Sontea – Furtuna lake-complexes [PDF]
Scientific Annals of the Danube Delta Institute, 2006 The fish catch from riverine Danube delta has changed in both structure and size. The average of catches decreased from 1747 t (1963 - 1974) to 252 t (1992 - 2003) in Gorgova–Uzlina lake-complex and from 1,634 t to 211 t in Sontea–Furtuna lake-complex ...
NAVODARU Ion, CERNISENCU Irina
doaj
Dynamics and Management of Stage-Structured Fish Stocks [PDF]
Bulletin of Mathematical Biology, 2013 With increasing fishing pressures having brought several stocks to the brink of collapse, there is a need for developing efficient harvesting methods that account for factors beyond merely yield or profit. We consider the dynamics and management of a stage-structured fish stock. Our work is based on a consumer-resource model which De Roos et al.
Meng, X. +3 more
openaire +4 more sources