Results 241 to 250 of about 16,637,647 (281)

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

“Low‐Positive” MOG‐IgG Cases Among Adults With a First Event Suggestive of Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the prevalence and clinical characteristics of patients with “low‐positive” (LP) MOG‐IgG (titres 1:160–1:320) among adults with a first demyelinating event (FDE) suggestive of multiple sclerosis (MS). Methods From the Barcelona CIS inception cohort, we included adult patients with serum collected ≤ 6 months from the FDE.
Javier Villacieros‐Álvarez, Carmen Espejo, Georgina Arrambide, Mireia Castillo, Marta Rodriguez, Helena Ariño, Iker Elosua, Carmen Tur, Angela Vidal‐Jordana, Andreu Vilaseca, Joaquín Castilló, Ingrid Galán, Luciana Midaglia, Carlos Nos, Breogan Rodríguez‐Acevedo, Ana Zabalza, Luca Bollo, Agustín Pappolla, René Carvajal, Neus Mongay‐Ochoa, Jordi Rio, Jaume Sastre‐Garriga, Manuel Comabella, Gesualdina Busiello, Sofia Sceppacuercia, Àlex Rovira, Xavier Montalban, Mar Tintoré, Cristina Auger, Álvaro Cobo‐Calvo   +29 more
wiley   +1 more source

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Vanishing Fisher Information

Acta Applicandae Mathematica, 2003
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Klaassen, C.A.J., Lenstra, A.J.
openaire   +3 more sources

Clocks and fisher information

Theoretical and Mathematical Physics, 2010
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Chen, Ping, Luo, Shunlong
openaire   +1 more source

On Nonparametric Estimation of the Fisher Information

2020 IEEE International Symposium on Information Theory (ISIT), 2020
This paper considers a problem of estimation of the Fisher information for location from a random sample of size n. First, an estimator proposed by Bhattacharya is revisited and improved convergence rates are derived. Second, a new estimator, termed clipped estimator, is proposed.
Wei Cao 0003, Alex Dytso, Michael Fauß, H. Vincent Poor, Gang Feng 0004   +4 more
openaire   +1 more source

Fisher Information for the Morse Oscillator

Reports on Mathematical Physics, 2020
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Chatterjee, Supriya, Sekh, Golam Ali, Talukdar, Benoy   +2 more
openaire   +1 more source

Fisher information distance: A geometrical reading

Discrete Applied Mathematics, 2015
15 pages, 8 ...
João E Strapasson, Sandra Cristina Veiga de Oliveira Santos, Sueli I R Costa   +2 more
exaly   +5 more sources

Complexity and Fisher information

Physical Review E, 2000
The connection between an observer-based theory of measurement and a hierarchical classification of complex systems in terms of topological exponents is discussed. This leads to generalized definitions of complexity that capture different aspects of the structure of the trajectory space of complex systems.
openaire   +2 more sources

Adaptive Control of Fisher Information

Cybernetics and Systems Analysis, 2005
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Banek, T., Kulikowski, R.
openaire   +2 more sources