Results 321 to 330 of about 1,060,583 (384)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Increasing Sea Surface Temperatures Driving Widespread Tropicalization in South Atlantic Pelagic Fisheries. [PDF]

Biology (Basel)
Sant'Ana R, Thá D, Henry LA, Schroeder R, Perez JAA.   +4 more
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Population Dynamics of Bigeye Grunt <i>Brachydeuterus auritus</i> (Valenciennes, 1831) in the Coastal Waters of Sierra Leone: A Near-Threatened Species on the IUCN Red List. [PDF]

Biology (Basel)
Zhao G, Feng C, Liu H, Qu T, Fan R, Coker ICR, Seisay LD, Huang H, Li L.   +8 more
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Diversity and Distribution of Deep-Sea Cetaceans in the Northern South China Sea Based on Visual and Acoustic Surveys. [PDF]

Animals (Basel)
Fang L, Wang X, Chen Y, Wang Y, Long X, Lu W, Zhao H, Zhen Z, Li K, Gutang Q, Chen T.   +10 more
europepmc   +1 more source

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

Global fisheries sustainability performance data collected from pre-assessments against the Marine Stewardship Council's fisheries standard. [PDF]

Data Brief
Rasal J, Melnychuk MC, Ferber S, Lejbowicz A, Montero-Castaño C, Longo C.   +5 more
europepmc   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Ocean conditions drive interannual variability in juvenile albacore tuna (Thunnus alalunga) muscle energy content in the California Current System. [PDF]

PLoS One
Nickels CF, Muhling BA, Portner EJ, Snodgrass OE, Dewar H.   +4 more
europepmc   +1 more source