Results 71 to 80 of about 820,460 (354)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Illuminating divergence in perceptions in natural resource management: A case for the investigation of the heterogeneity in mental models

open access: yesJournal of Dynamic Decision Making, 2018
Much research has been dedicated to map mental models of natural resources to aid effective management of the natural resource. The variety of approaches result in a variety of outputs, but most research in this domain reports mental models that have ...
Karlijn van den Broek
doaj   +1 more source

The Swedish Fisheries [PDF]

open access: yesNature, 1882
IN NATURE of April 20 you ask for an explanation of the difference in the figures of Dr. Oscar Dickson and Dr. Lundberg relating to the Swedish fisheries.
openaire   +2 more sources

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

Science and Fisheries [PDF]

open access: yesNature, 1921
THE two letters from Prof. McIntosh and Mr. H. G. Maurice published in NATURE of December 30 last are of great interest. The second points out that an arrangement is now in operation by which the scientific staffs of the English, Scottish, and Irish Fishery Departments are arranging to meet at regular intervals to frame their scientific programmes; and
openaire   +3 more sources

Community Fisheries Development Office (CFDO) strategic plan, January 2004 [PDF]

open access: yes, 2004
In October 2000 the government of Cambodia announced a major change in fisheries management policy. The core elements of the new policy are the reduction of fishing lot concession areas by 56%, the broader participation of fishing communities in the ...

core  

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

open access: yesMolecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker   +14 more
wiley   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

open access: yesMolecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen   +13 more
wiley   +1 more source

Introduction to Fisheries Economics

open access: yes, 2016
Text book in fisheries economics and Mathematica programming.EARLY ...
openaire   +2 more sources

Lune, Wyre & Furness Fisheries Advisory Committee 19th January, 1976. [PDF]

open access: yes, 1976
This is the report from the Lune, Wyre and Furness Fisheries Advisory Committee meeting, which was held on the 19th January 1976. The report contains information on land drainage representation on local committees, fisheries activities report, Heysham ...

core  

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