Results 91 to 100 of about 929,427 (333)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

'Politics plays key role in fisheries governance’ The Hindu 11th April 2017 [PDF]

open access: yes, 2017
Politics, rather than science, played a key role in marine fisheries governance in South Asia, said Maarten Bavinck, a Dutch scientist specialised in the capture fishery of India and Sri Lanka.
CMFRI, Library
core  

Report of the Regional Workshop Towards a New Era of Support for Small-scale Fisheries in Southeast Asia [PDF]

open access: yes, 2023
The Regional Workshop on Towards a New Era of Support for Small-scale Fisheries in Southeast Asia was organized on 29‒31 August 2023. The Workshop was aimed at 1) compiling the description/recognition/contribution of SSF in the region (or in each country)
Training Department, Southeast Asian Fisheries Development Center
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Brexit and the future of UK fisheries governance: learning lessons from Iceland, Norway and the Faroe Islands

open access: yesContemporary Social Science, 2018
Brexit presents significant challenges and uncertainties for the future governance of policy areas currently managed by the EU. This is especially the case with fisheries policy.
C. Huggins   +3 more
semanticscholar   +1 more source

Enhancing Governance in Fishery Management

open access: yes, 2011
Fisheries is an important sector that provides substantial contribution to people’s food security and well-being, poverty alleviation, and economic development.

core  

National Training Course “Essential‐Ecosystem Approach to Fisheries Management” [PDF]

open access: yes, 2015
The Food and Agriculture Organization of the United Nations (“FAO”) and the Department of Fisheries, Thailand has signed the Letter of Agreement (LOA) for the execution of the GEF supported project “Strategies for trawl fisheries by‐catch management ...
Supongpan, Mala
core  

Stakeholder Analysis of Small-Scale Fisheries in Bunyu Island, North Kalimantan, Indonesia

open access: yesGrouper
Small-scale fisheries in Bunyu Island, North Kalimantan, hold a strategic position in supporting Indonesia’s maritime border economy. Various stakeholders are involved in the management of small-scale fisheries in the island.
Taufiq Romdoni   +7 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

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