Results 121 to 130 of about 929,427 (333)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Ocean Back: Inuit-led Governance for the Future of Fisheries in Nunatsiavut

, 2023
Fisheries governance represents a key opportunity for upholding the rights of Indigenous Peoples in Canada. But how to fulfill these rights, and how to ensure that Indigenous Knowledges, values, and priorities guide management remains a challenge.
Cadman, Rachael
core  

Small-Scale Fisheries (SSF) Characteristics and Governance Challenges in Lagos State, Nigeria

Davao Research Journal
Small-scale fisheries (SSF) are crucial to the local economy, providing food, income, and employment. However, they face challenges such as inadequate government support, limited fisher involvement in decision-making, and poor conflict resolution ...
Shehu L Akintola, Akinkunmi S Ojo, Rosheedah A Adeniji, Olubukola O Sogbesan   +3 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Food security and poverty alleviation through improved valuation and governance of river fisheries in Africa [PDF]

The project aims to sustain and improve the livelihoods of the rural poor who depend on fisheries for their employment, income and food security along the rivers of the Lake Chad and Zambezi basins.
BΘnΘ, C.
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Reimagining large-scale open-water fisheries governance through adaptive comanagement in hilsa shad sanctuaries

, 2018
Almost a half million fishers in Bangladesh are predominantly reliant on the hilsa shad (Tenualosa ilisha) fishery in the Meghna River and estuarine ecosystem. This paper adopts a broadened concept of social-ecological traps to frame the complex dynamics
M. V. Brakel, Nahiduzzaman, A. Haque, Mustafa, Rahman, Wahab   +5 more
semanticscholar   +1 more source

Proposing Dimensions of an Agroecological Fishery: The Case of a Small-Scale Indigenous-Led Fishery Within Northwest Territories, Canada

Conservation
As fisheries face intersecting ecological and economic crises, small-scale fishers and Indigenous fishing communities have been organising globally to protect their rights.
Charlotte Spring, Jennifer Temmer, Kelly Skinner, Melaine Simba, Lloyd Chicot, Andrew Spring   +5 more
doaj   +1 more source

Managing small-scale commercial fisheries for adaptive capacity: insights from dynamic social-ecological drivers of change in Monterey Bay.

PLoS ONE, 2015
Globally, small-scale fisheries are influenced by dynamic climate, governance, and market drivers, which present social and ecological challenges and opportunities.
Stacy E Aguilera, Jennifer Cole, Elena M Finkbeiner, Elodie Le Cornu, Natalie C Ban, Mark H Carr, Joshua E Cinner, Larry B Crowder, Stefan Gelcich, Christina C Hicks, John N Kittinger, Rebecca Martone, Daniel Malone, Carrie Pomeroy, Richard M Starr, Sanah Seram, Rachel Zuercher, Kenneth Broad   +17 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source