Results 131 to 140 of about 12,866 (216)

Identification of Histone Deacetylase Inhibitor Targeting Type I Interferon and B Cell Abnormalities in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is characterized by increased Type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

Only One Percent of Important Shark and Ray Areas in the Western Indian Ocean Are Fully Protected From Fishing Pressure. [PDF]

Ecol Evol
Cochran JEM, Charles R, Temple AJ, Kyne PM, García-Rodríguez E, Gonzalez-Pestana A, Batlle-Morera A, Mouton TL, Armstrong AO, Rohner CA, Coker DJ, Hardenstine RS, Kattan A, McIvor AJ, Peinemann VN, O'Toole KA, Palm L, Richardson EB, Akhilesh KV, Ali Abedi H, Almealla RK, Almojil D, Andrzejaczek S, Askin AN, Banerjee AA, Bargahi HR, Barnes AJ, Barteneva-Vitry S, Behzadi S, Bein A, Bennett RH, Bocchi F, Boldrocchi G, Braulik GT, Braun CD, Brighton E, Budd FKP, Bullock RW, Canovas Perez C, Carlisle AB, Carpenter M, Chapple TK, Chaúca I, Cliff G, Crochelet E, Cullain N, Curnick DJ, Daly R, de Necker L, Diamant S, Donati GFA, Ebert DA, Eid E, Elhassa IS, Elston C, Everett BI, Farrag MMS, Fassbender N, Fennessy ST, Fernando SMC, Finucci B, Flam AL, Gausman P, Gauthier ARG, Sreekanth GB, Gupta T, Hafeez M, Hagy BN, Haines JLA, Harris JL, Harvey-Carroll J, Hempson TN, Hilbourne ST, Hsu HH, Ibrahim ND, Jacoby DMP, Jaquemet S, Babu K K I, Karnad D, Kaunda-Arara B, Kizhakudan SJ, Kock AA, Koester A, Kuboja BN, Kuguru BL, Lea JSE, Mahadalle O, Manjebrayakath H, Mason-Parker C, Mateos-Molina D, Menon M, Moore ABM, Mourier J, Murra TS, Nakhawa AD, Nazurally N, Nelso LE, Nevill JEG, Olbers JM, Ostrovski RL, Peel LR, Perisic N, Peterson B, Pierce SJ, Pittman SJ, Rahangdale S, Rambahiniarison J, Rastgoo AR, Rezaie-Atagholipour M, Robinson DP, Samoilys MA, Sawers TJ, Scannell BJ, Schmidt JV, Silva IM, Silva L, Solonomenjanahary J, Spaet JLY, Stevens GMW, Strike EM, Thomas S, van Beuningen D, Venables SK, Vossgaetter L, Weideli OC, Williams ID, Williams CT, Willson AJ, Wilson L, Zareer IH, Zerr KM, Berumen ML, Jabado RW.   +132 more
europepmc   +1 more source

Multi‐omic profiling reveals immune cell priming signature linked to lupus prognosis

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is a multi‐organ disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

RETRACTED: Shu et al. Using Stable Isotope Techniques to Analyze the Trophic Relationship between Argentine Hake (<i>Merluccius hubbsi</i>) and Anisakidae. <i>Biology</i> 2024, <i>13</i>, 515. [PDF]

Biology (Basel)
Shu Y, Wu F, Fang Z.
europepmc   +1 more source

Data, not documents: Moving beyond theories of information‐seeking behavior to advance data discovery

Journal of the Association for Information Science and Technology, Volume 76, Issue 4, Page 649-664, April 2025.
Abstract Many theories of human information behavior (HIB) assume that information objects are in text document format. This paper argues four important HIB theories are insufficient for describing users' search strategies for data because of assumptions about the attributes of objects that users seek.
Anthony J. Million, Jeremy York, Sara Lafia, Libby Hemphill   +3 more
wiley   +1 more source

Rethinking the Blue Economy: Integrating social science for sustainability and justice. [PDF]

NPJ Ocean Sustain
Penca J, Ertör I, Ballesteros M, Briguglio M, Kowalewski M, Pauksztat B, Cepić D, Piñeiro-Corbeira C, Vaidianu N, Villasante S, Pascual-Fernández JJ.   +10 more
europepmc   +1 more source

Adverse Childhood Experiences in Autistic and Neurotypical Girls

Autism Research, EarlyView.
ABSTRACT Adverse childhood experiences (ACEs) are potentially traumatic, life‐altering events that occur in childhood with long‐term negative physical and/or mental health outcomes. Previous research, while limited and largely focused on males, suggests children with autism spectrum disorder (ASD) are at higher risk of experiencing ACEs than typically ...
Jon Ebert, Rachael A. Muscatello, Trey McGonigle, Simon Vandekar, Blythe A. Corbett   +4 more
wiley   +1 more source

Mainstreaming a gender perspective into food system policies for healthy diets in low- and middle-income countries: a policy landscape analysis. [PDF]

Glob Health Action
Venance MS, Reeve E, Alokpaï N, Borazon EQ, Perera S, Thow AM, Harris J.   +6 more
europepmc   +1 more source

The integration of the British Pharmacological Society's prescription safety assessment into the WHO 6‐step model of rational pharmacotherapy in a Turkish medical school

British Journal of Clinical Pharmacology, EarlyView.
Aims At Koç University School of Medicine, a one‐week rational pharmacotherapy (RPHM) programme, modelled after WHO 6‐step, has been introduced in the fourth‐year curriculum to improve prescription skills. For efficient problem‐based learning (PBL) sessions on a prespecified topic, students need to brush up on basic pharmacology knowledge, so we ...
Sinem Ezgi Gülmez, Gülnihal Özcan, Hakan S. Orer   +2 more
wiley   +1 more source

Creative environmental engineering' and the cost of environmental claims: legitimisation of tire artificial reefs by us federal scientists in 1960s-1970s. [PDF]

Hist Philos Life Sci
Porsnovs D.
europepmc   +1 more source