Results 181 to 190 of about 1,700 (296)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Proceedings of the Technical Seminar on South China Sea Fisheries Resources, Bangkok, Thailand, 21-25 May 1973

open access: yes, 1977
The approach to the stock assessment and fishery management is briefly described on the Indo-Pacific mackerel resource in the Gulf of Thailand and the yellowtail resource around the Pacific coast of Japan. Recently, the fishery forecast has become one of
Kurogane, Kenji
core  

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Fishing fleets as ecosystem sentinels. [PDF]

open access: yesProc Natl Acad Sci U S A
Welch H   +11 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Risk of capture is modified by hypoxia and interjurisdictional migration of Lake Whitefish (Coregonus clupeaformis). [PDF]

open access: yesSci Rep
Kraus RT   +6 more
europepmc   +1 more source

An ecosystem-based fisheries assessment and forecasting approach

open access: yesAn ecosystem-based fisheries assessment and forecasting approach
A comprehensive ecosystem-based approach is required to holistically assess, forecast and manage fisheries resources and their associated habitats by considering ecological interactions of target species with predators, competitors, and prey species, interactions between fishes and their habitats, and the effects of fishing on these processes.
openaire  

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