Results 201 to 210 of about 1,079 (255)

Medium and long-term regional water demand prediction using Harris hawks optimisation-backpropagation neural network model. [PDF]

Sci Rep
Yang M, Gao E, Wang G, Li D, Zhou W, Zhou X.   +5 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

An integrating RAG-LLM and deep Q-network framework for intelligent fish control systems. [PDF]

Sci Rep
Danvirutai P, Charoenwattanasak S, Tola S, Thaiso K, Yuangsoi B, Minh HT, Srichan C.   +6 more
europepmc   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Filling the gap: artificial intelligence-driven one health integration to strengthen pandemic preparedness in resource-limited settings. [PDF]

Front Public Health
Mukherjee D, Sagar K, Kobialka RM, Ghosh P, Weidmann M, Savareh BA, Joardar SN, Truyen U, Abd El Wahed A, Ceruti A.   +9 more
europepmc   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Designing gender-inclusive data systems in small-scale fisheries. [PDF]

Ambio
Harper SJ, Williams M, Kleiber D, Axelrod M, Mangubhai S, Torell E, Macho G, Fakoya K, Gopal N, Ojea E, Lawless S, Franz N, de la Torre-Castro M, Deeg C, Gustavsson M, Oloko A, Atkins M, Basurto X, Soejima K, Ferrer AJ, Del Mar Mancha-Cisneros M, Pedroza-Gutiérrez C, Choudhury A, Cohen PJ, Siegelman B, Bradford K, Duffy-Tumasz A, Fröcklin S, Gee J, Kusakabe K, Appiah S, Manyungwa-Pasani C, Virdin J, Sutaria SS, Siyanbola O, McDougall C.   +35 more
europepmc   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

The review of the evolution, deficiencies, and future outlook of China's pelagic fisheries management from 1985 to 2024. [PDF]

Heliyon
Chu X.
europepmc   +1 more source