Results 41 to 50 of about 10,722 (263)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

The Canadian Fisheries Industry: Retrospect and Prospect

open access: yesCanadian Political Science Review, 2007
Without question, Canadian domestic policy has had an influence on the development of the fisheries staple industry – from its National Policy to its subsidization of both fishers and, more recently its effort to conserve of fish stocks. In this respect Laxer is correct in allocating “blame” for the current dire status of the fisheries industry where ...
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

KEBIJAKAN KERAJAAN DAN PERTUMBUHAN INDUSTRI PERIKANAN DI SELAT MALAKA SEBELUM PENJAJAHAN

open access: yesHumanus: Jurnal Ilmiah Ilmu-ilmu Humaniora, 2019
This paper aims to prove the relation of Siak Kingdom policy to fishery industry in Malacca Strait. Because the Strait Malacca have rich by fishes. The archeologis fact eksplans many of clem shell of wasting of the coastal communities wastes.
Azmi Fitrisia
doaj   +1 more source

Effects of Dietary Alpha-Lipoic Acid on Growth Performance, Serum Biochemical Indexes, Liver Antioxidant Capacity and Transcriptome of Juvenile Hybrid Grouper (Epinephelus fuscoguttatus♀ × Epinephelus polyphekadion♂)

open access: yesAnimals, 2023
We aimed to investigate the effects of dietary alpha-lipoic acid (α-LA) on the growth performance, serum biochemical indexes, liver morphology, antioxidant capacity, and transcriptome of juvenile hybrid groupers (Epinephelus fuscoguttatus♀ × Epinephelus ...
Guanghai Ou   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Disintegration of Oki Fishery Industry

open access: yesGeographical Review of Japan, 1951
The Oki Islands, or the Province of Oki, as described in “Engishiki” a court document of the 11th century, was noted forr her fishery products. In the amount of the products, according to the above document, Oki ranked third, the other two being Wakasa and Shima. Dried sea-ears, boiled sea-cucumber and dried cattle-fish were the principal products.
openaire   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Fisheries industry strategy in Indonesia

open access: yesIOP Conference Series: Earth and Environmental Science, 2020
Abstract Over the past few years, fishery growth has always exceeded economic growth in Indonesia. Based on this performance, more focused policies are needed to manage it. This study aims to develop a strategy for the fishing industry, specifically related to the center of the fisheries processing industry in Indonesia, with a ...
null Miar   +4 more
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

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