Results 41 to 50 of about 10,640 (262)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Industrialization in fisheries: a challenge to change
Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology, 2014 To manage with the Indonesian vision as the biggest producer of fisheries in 2015, capture,aquaculture, and post-harvest fisheries should be ready to operate at large or business scale.Consequently, industrialization should be promoted since this is the most appropriate way tomanage fisheries in business manner.
Achmad Poernomo, Endang Sri Heruwati
openaire +3 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
KEBIJAKAN KERAJAAN DAN PERTUMBUHAN INDUSTRI PERIKANAN DI SELAT MALAKA SEBELUM PENJAJAHAN
Humanus: Jurnal Ilmiah Ilmu-ilmu Humaniora, 2019 This paper aims to prove the relation of Siak Kingdom policy to fishery industry in Malacca Strait. Because the Strait Malacca have rich by fishes. The archeologis fact eksplans many of clem shell of wasting of the coastal communities wastes.
Azmi Fitrisia
doaj +1 more source
Animals, 2023 We aimed to investigate the effects of dietary alpha-lipoic acid (α-LA) on the growth performance, serum biochemical indexes, liver morphology, antioxidant capacity, and transcriptome of juvenile hybrid groupers (Epinephelus fuscoguttatus♀ × Epinephelus ...
Guanghai Ou +8 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The Canadian Fisheries Industry: Retrospect and Prospect
Canadian Political Science Review, 2007 Without question, Canadian domestic policy has had an influence on the development of the fisheries staple industry – from its National Policy to its subsidization of both fishers and, more recently its effort to conserve of fish stocks. In this respect Laxer is correct in allocating “blame” for the current dire status of the fisheries industry where ...
openaire +2 more sources
Fisheries industry strategy in Indonesia
IOP Conference Series: Earth and Environmental Science, 2020 Abstract Over the past few years, fishery growth has always exceeded economic growth in Indonesia. Based on this performance, more focused policies are needed to manage it. This study aims to develop a strategy for the fishing industry, specifically related to the center of the fisheries processing industry in Indonesia, with a ...
null Miar +4 more
openaire +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source