Results 41 to 50 of about 30,785 (306)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Inheritance and Development: The Evolution and Overview of China’s Fisheries Legal System

Fishes, 2022
China’s legal system governing fisheries in China has been stable during development. In line with China’s national conditions and the spirit of the times, they have adhered to the concept of green development and maintaining the sustainable development ...
Wei Wu, Yang Liu, Zhaobin Pei, Yan Lin, Xin Sun, Jiaqi Xing, Yuwei Wang, Yu Liu   +7 more
doaj   +1 more source

True insights or ticking boxes? Rapid assessment of rights‐based management in artisanal fisheries [PDF]

, 2023
Andrés M. Cisneros‐Montemayor, Eréndira Aceves‐Bueno, Sergio Amezcua‐Castro, Alejandra Apolinar‐Romo, Frida Cisneros‐Soberanis, Gabriela Alejandra Cuevas‐Gómez, Ingrid C. Cruz‐León, Javier De La Cruz‐González, Alejandro Espinoza‐Tenorio, Alejandro García‐Lozano, Pedro C. González‐Espinosa, Miguel Ángel Cisneros‐Mata   +11 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Contributions of small‐scale and longline fishing to sea turtle mortality in the Solomon Islands

Conservation Letters
A focus of sea turtle management has been reducing bycatch in commercial fisheries, but sustainable harvest for consumption is also an important objective in many nations. Identifying how much different fisheries contribute to turtle mortality could help
Christopher Brown, Richard Hamilton, Simon Vuto, Willie Atu, Rosalie Masu, Christain Ramofafia, Pete Waldie   +6 more
doaj   +1 more source

Rebuilding the Northeast Arctic Cod Fisheries – Economic and Social Issues

Arctic Review on Law and Politics, 2014
The Northeast Arctic cod (NEA cod) fisheries in Norway are now one of the richest cod fisheries in the world. In the past the fishery has experienced several stock declines and low economic returns.
Claire W. Armstrong, Arne Eide, Ola Flaaten, Knut Heen, Inga Wigdahl Kaspersen   +4 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Collective action in fishery resource management and its challenges in Ethiopia: a review

Discover Food
Natural resources such as fish are vital for improving human livelihood and serving as sources of food, income and employment opportunities in Ethiopia. But, its degradation and overexploitation lead to anxiety about the living standards of human beings ...
Oliyad Sori Zenbaba
doaj   +1 more source

An indicator‐based decision framework for the northern California red abalone fishery

Ecosphere, 2019
Among abalone species that were once harvested along the California coastline, red abalone (Haliotis rufescens) supports the remaining recreational fishery.
William J. Harford, Natalie A. Dowling, Jeremy D. Prince, Frank Hurd, Lyall Bellquist, Jack Likins, Jono R. Wilson   +6 more
doaj   +1 more source