Results 81 to 90 of about 180,043 (297)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Small-scale fisheries of San Miguel Bay, Philippines: biology and stock assessment [PDF]
Small scale fisheries, Fishery biology, Fishery resources, Stock assessment, Collected papers, San Miguel Bay, Philippines,
Mines, A.N. (eds.), Pauly, D.
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Alternative Management Regimes for multiple species fisheries [PDF]
This empirical study examines welfare gains and losses that would result from alternative fishery management regimes. In an application to the North Sea demersal fisheries, the study shows that these fishery resources can give rise to large economic rent.
Kim, Chungsoo
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Harvesting natural resources: management and conflicts [PDF]
It is reasonable to consider the stock of any renewable resource as a capital stock and treat the exploitation of that resource in much the same way as one would treat accumulation of a capital stock.
Halkos, George
core +1 more source
Lake Victoria Fisheries Management Plan [PDF]
, 2001 The purpose of this Fisheries Management Plan (FMP) within the Lake Victoria Fisheries Research Project was to sustain the livelihoods of the communities who depend on the fishery resources of the lake and to reduce poverty, food insecurity and ...
Bwathondi, P.O.J. +2 more
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Responses of coastal fishery resources to rapid environmental changes. [PDF]
J Fish Biol, 2022 Peltonen H, Weigel B.
europepmc +1 more source
Use of a fishery independant index to predict recruitment and catches of the spiny lobster [PDF]
This paper presents a review of recruitment and catch predictions based on an index of abundance of juveniles and pre-recruits (fishery independent index) in the Cuban lobster fisheries.
Adriano, R., Cruz, R.
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