Results 141 to 150 of about 1,280,730 (308)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The latitudinal speciation gradient in freshwater fishes: Higher speciation across assemblages at higher latitudes in the northern hemisphere. [PDF]

PLoS One
Herrera-Pérez J, Carvajal-Quintero J, Arango A, Valencia-Rodríguez D, García-Andrade AB, Tedesco P, Villalobos F.   +6 more
europepmc   +1 more source

Extraction of Type-I Collagen from Sea Fish and Synthesis of Hap/Collagen Composite

, 2014
Pranabesh Kumar Sasmal, Howa Begam
openalex   +1 more source

The determination of standard metabolic rate in fishes.

Journal of Fish Biology, 2016
D. Chabot, J. Steffensen, A. Farrell
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

ManyFishes: a big team science collaboration on fish comparative cognition. [PDF]

Anim Cogn
Prétôt L, Agrillo C, Bluck BC, Cabrera-Álvarez MJ, Héjja-Brichard Y, Irwin K, Klinke A, Lucon-Xiccato T, Newport C, Segev R, Yeager J.   +10 more
europepmc   +1 more source

Molecular Assays for DetectingAphanomyces invadansin Ulcerative Mycotic Fish Lesions

, 2006
Mark W. Vandersea, R. Wayne Litaker, Bryan Yonnish, Emilio R. Sosa, Jan H. Landsberg, Chris Pullinger, Paula Moon-Butzin, Jason Green, James A. Morris, Howard Kator, Edward J. Noga, Patricia A. Tester   +11 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Parental investment and body temperature explain encephalization in vertebrates. [PDF]

Proc Natl Acad Sci U S A
Song Z, Griesser M, van Schaik CP.
europepmc   +1 more source

Orientation saliency without visual cortex and target selection in archer fish

, 2010
Alik Mokeichev, Ronen Segev, Ohad Ben‐Shahar   +2 more
openalex   +2 more sources