Results 161 to 170 of about 1,577,442 (403)

Big fish, little fish [PDF]

open access: yesThe Journal of Thoracic and Cardiovascular Surgery, 2016
Dirk J, Varelmann, Michael N, D'Ambra
openaire   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Replacing sea mud with attachment of suspension cage can improve growth and gut health for sea cucumber Apostichopus japonicus

open access: yesFrontiers in Marine Science
During the suspension cage culture procedure, a substantial quantity of attachments from the suspension cage will amass in the tidal flats, resulting in environmental pollution and resource wastage.
Zhixu Guo   +13 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Influences of water velocity on ovarian maturation and antioxidant capacity in adult grass carp (Ctenopharyngodon idellus)

open access: yesFrontiers in Marine Science
Ecological operation of hydraulic engineering is essential for the conservation of fishery resources. Water velocity is known to affect the spawning of fishes delivering drifting eggs.
Tingting Shu   +14 more
doaj   +1 more source

Synopsis of biological data on the cobia Rachycentron canadum (Pisces: Rachycentridae) [PDF]

open access: yes, 1989
Information on the biology and fisheries of cobia, Rachycentron canadum, is compiled and reviewed in the FAD species synopsis style. Topics include taxonomy, morphology, distribution, reproduction, pre-adult and adult stages, food, growth, migration ...
Nakamura, Eugene L.   +1 more
core  

Insights into the Social Behavior of Surface and Cave-Dwelling Fish (Poecilia mexicana) in Light and Darkness through the Use of a Biomimetic Robot [PDF]

open access: gold, 2018
David Bierbach   +12 more
openalex   +1 more source

Detection and characterization of lipids in eleven species of fish by non-targeted liquid chromatography/mass spectrometry

open access: bronze, 2022
Siddabasave Gowda B. Gowda   +4 more
openalex   +2 more sources

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