Results 171 to 180 of about 1,280,730 (308)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Long-Term and Regional-Scale Data Reveal Divergent Trends of Different Climate Variables on Fish Body Size Over 75 Years. [PDF]

Glob Chang Biol
Flood PJ, Schiller KE, King KBS, Runyon AD, Wehrly KE, Alofs KM.   +5 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Elemental Homeostasis Deciphers the Multidimensional Stoichiometric Niche of Fish Communities in the Beibu Gulf. [PDF]

Ecol Evol
Wang C, Huang L, Zhao S, Yang Y, She P, Chen J, Wu H, Yang X, Song S.   +8 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Early Biogeography of Otophysi Points to the Neotropics as the Cradle of Characiphysan Fishes. [PDF]

Ecol Evol
Lenglin A, Hidalgo M, Miranda G, De la Sota A, Caminade P, Belkhir K, Otero O, Antoine PO, Garcia-Davila C, Hubert N.   +9 more
europepmc   +1 more source

Potential of Fish Wastes as Feedstock for Biodiesel

, 2019
Sujjat Al Azad, Lai Yee Wuen, Mohammad Tamrin Mohamad Lal   +2 more
openalex   +2 more sources

River Herring Conservation in Freshwater: Investigating Fish Reproductive Success and the Educational Value of Citizen Monitoring Programs

, 2021
Meghna N. Marjadi
openalex   +2 more sources

Patterns of Life-History Diversification in North American Fishes: implications for Population Regulation

, 1992
K. Winemiller, K. Rose
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source