Results 51 to 60 of about 1,280,730 (308)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanism of Biphasic Activation of NLRP3 Inflammasome in the Fat Greenling (Hexagrammos otakii) Under Hypoxic Stress: From Inflammatory Defense to Pyroptosis Execution

Fishes
Hypoxic stress is an important environmental challenge for aquatic organisms, which is detrimental to fish survival and growth. Specifically, the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) has emerged as a pivotal regulator ...
Yiting Wu, Ling Zhao, Xinying Zhang, Rangman Liu, Dongxu Gao, Junru Su, Lei Peng, Yuan Liu, Yuqing Yan, Zhuang Xue, Wei Wang   +10 more
doaj   +1 more source

The complete mitochondrial genome of Ancherythroculter wangi and its phylogeny

Mitochondrial DNA. Part B. Resources, 2018
Ancherythroculter wangi, is a unique freshwater fish and mainly distributed in the upper stream of Yangtze River and its tributary. In this study, the complete mitochondrial genome of A. wangi was first determined.
Yuanchao Zou, Junying Zhang, Meng Xie, Tao Zhang, Qi Deng, Zhengyong Wen   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Hindering the biofilm of microbial pathogens and cancer cell lines development using silver nanoparticles synthesized by epidermal mucus proteins from Clarias gariepinus

BMC Biotechnology
Scientists know very little about the mechanisms underlying fish skin mucus, despite the fact that it is a component of the immune system. Fish skin mucus is an important component of defence against invasive infections. Recently, Fish skin and its mucus
Ahmed N. Alabssawy, Mohammed Abu-Elghait, Ahmad M. Azab, Hassan M. M. Khalaf-Allah, Abdelrahman S. Ashry, Ahmed O. M. Ali, Abu-Bakr A. A. Sabra, Salem S. Salem   +7 more
doaj   +1 more source

Sequence identification and phylogenetic analysis of the mitochondrial genome of Microphysogobio kiatingensis (Cypriniformes: Cyprinidae)

Mitochondrial DNA. Part B. Resources, 2018
Microphysogobio kiatingensis is endemic freshwater fish of China and mainly distributed in the middle and upper reaches of the Yangtze River. The complete mitogenome of M.
Yuanchao Zou, Junying Zhang, Tao Zhang, Meng Xie, Tian Wu   +4 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The Evolution of Three Schizothoracinae Species from Two Major River Systems in Northwest China Based on Otolith Morphology and Skeletal Structure

Biology
Schizothoracinae species are the largest group of Cypriniformes that readily adapt to the natural conditions of the Qinghai-Tibet Plateau. This group has habitat characteristics and distribution patterns centered on the Qinghai-Tibet Plateau.
Chengxin Wang, Linghui Hu, Yong Song, Haoyang Xie, Liting Yang, Gulden Serekbol, Bin Huo, Shengao Chen   +7 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Telomere-to-telomere reference genome of Rhinogobio nasutus, an endangered endemic fish from the Yellow River

Scientific Data
Rhinogobio nasutus is an endemic fish species native to the middle and upper reaches of the Yellow River in China, renowned for its high economic and nutritional value. However, due to overfishing, human activities, and environmental pollution, it is now
Changping Jiang, Yanyan Du, Zhongyu Lou, Yanping Zhang, Tai Wang   +4 more
doaj   +1 more source