Results 171 to 180 of about 897,105 (339)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Musculoskeletal Disorders and Psychological and Environmental Factors Associated with Recreational and Sport Fishing: A Narrative Review. [PDF]
Pędrasik P, Wilczyński B, Zorena K.
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Reconstructing the spatial and temporal dynamics of Ecuador's artisanal small-scale fisheries from fishers' perspective. [PDF]
Peñaherrera-Palma CR +6 more
europepmc +1 more source
Indonesia’s Decision to Share Data of Vessel Monitoring System with Global Fishing Watch
Presya Ramadhan, Vinsensio Dugis
openalex +1 more source
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Multivariate Gas Sensor E-Nose System with PARAFAC and Machine Learning Modeling for Quantifying and Classifying the Impact of Fishing Gears. [PDF]
Silva-Alvarado VL, Lloret J.
europepmc +1 more source

