This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga+8 more
wiley +1 more source
Stock assessment and management implications of sailfin sandfish (<i>Arctoscopus japonicus</i>) caught by multiple fishing gears with different selectivity in Korean waters. [PDF]
Lee SI, Kim EG, Yang JH, Zhang CI.
europepmc +1 more source
We investigated whether hypomethylating agents (HMAs) used in myeloid malignancies induce somatic retrotransposition. Our findings indicate that HMA treatment increases L1‐encoded protein expression but does not lead to detectable de novo retrotransposition events in either patient samples or cell lines.
Šárka Pavlová+14 more
wiley +1 more source
Spatiotemporal distribution and fishing ground driving mechanism of swimming crab Portunus trituberculatus in Hangzhou Bay and its adjacent waters. [PDF]
Xu G, Zhang H, Zhou Y.
europepmc +1 more source
Effects of turbidity on fish and fishing / by D. Homer Buck.
D. Homer Buck
openalex +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy+9 more
wiley +1 more source
Seasonal Spatial Distribution Patterns and Climate Scenario Predictions of <i>Palaemon gravieri</i>: A Key Shrimp Species Depressing Jellyfish Blooms in the East China Sea Region. [PDF]
Xu M, Ling J, Zheng H, Song X, Li H.
europepmc +1 more source
Fly-fishing and worm-fishing for salmon, trout and grayling
H. Cholmondeley-Pennell
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Emerging role of ARHGAP29 in melanoma cell phenotype switching
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster+3 more
wiley +1 more source