Results 121 to 130 of about 388,975 (339)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Ending Overfishing in Europe's North-Western Waters [PDF]
, 2015 Fisheries management in the European Union entered a new era in 2014 when the reformed Common Fisheries Policy (CFP) came into force stipulating an end to overfishing in EU waters and the restoration of fish stocks.
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Fishing power, fishing effort, density, fishing intensity and fishing mortality
ICES Journal of Marine Science, 1976 M. J. Sanders, A. J. Morgan
openaire +1 more source
The Bioeconomic Implications of A Bycatch Reduction Device as a Stock Conservation Management Measure [PDF]
The proposed regulation to reduce bycatch and discarding of finfish in the southeastern region is a gear modification that excludes finfish from shrimp trawls.
Ward, John M.
core +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Aquaculture-Fisheries Interactions [PDF]
In this paper, I investigate aquaculture externalities on fisheries, affecting either habitat, wild fish stock genetics, or fishing efficiency under open-access and rent-maximising fisheries. This is done with a Verhulst-Schaefer model of fish population-
Mikkelsen, Eirik
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source