Results 41 to 50 of about 3,148 (261)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Food from the Depths of the Mediterranean: The Role of Habitats, Changes in the Sea-Bottom Temperature and Fishing Pressure

Foods, 2022
As part of the “Innovations in the Food System: Exploring the Future of Food” Special Issue, this paper briefly reviews studies that highlight a link between deep-sea fishery resources (deep-sea food resources) and vulnerable marine ecosystems (VME ...
Porzia Maiorano, Francesca Capezzuto, Angela Carluccio, Crescenza Calculli, Giulia Cipriano, Roberto Carlucci, Pasquale Ricci, Letizia Sion, Angelo Tursi, Gianfranco D’Onghia   +9 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Stress Induced by Fishing in Common Octopus (Octopus vulgaris) and Relative Impact on Its Use as an Experimental Model

Animals
The common octopus (Octopus vulgaris), among coleoid cephalopods, has evolved the most complex nervous system and sophisticated behaviors. Historically, O.
Valeria Maselli, Mariangela Norcia, Bruno Pinto, Emanuela Cirillo, Gianluca Polese, Anna Di Cosmo   +5 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Macroinvertebrata Recruitments in Artificial Reef After Two Years of Sinking on The Damas Beach, Trenggalek

Journal of Marine and Coastal Science, 2020
The condition of coral reefs in Damas Beach is included in the bad category because there are many fragments of coral reefs (rubble) caused by fishing nets caught in the reef.
Shafa Thasya Thaeraniza, Oktiyas Muzaky Luthfi, Andik Isdianto   +2 more
doaj   +1 more source

Neural innovations and the diversification of African weakly electric fishes [PDF]

Communicative & Integrative Biology, 2011
In African mormyrid fishes, evolutionary change in a sensory region of the brain established an ability to detect subtle variation in electric communication signals. In one lineage, this newfound perceptual ability triggered a dramatic increase in the rates of signal evolution and species diversification.
Bruce A, Carlson, Matthew E, Arnegard
openaire   +2 more sources

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Adoption of Improved Artisanal Fishing Innovations among Fisherfolks in Delta State, Nigeria

Journal of Agricultural Extension
Innovations in artisanal fishing are indispensable and help artisanal fishermen to increase their harvest. The study examined the extent of adoption of artisanal fishing innovations among artisanal fisherfolks in Delta State, Nigeria. Data for the study
MICHAEL CHUKWUEMEKA UMEHAI
doaj   +2 more sources