Canagliflozin enhances hippocampal function, reduces Aβ pathology, and improves cognitive function in male mice, while females show limited benefits, revealing sex‐specific neuroprotective responses across aging and Alzheimer's models. ABSTRACT Aging is the strongest risk factor for cognitive decline and Alzheimer's disease (AD), yet the mechanisms ...
Hashan Jayarathne +11 more
wiley +1 more source
Physiological roles of lignins – tuning cell wall hygroscopy and biomechanics
Summary Lignins constitute the second most abundant carbon‐storing biopolymers in the biosphere. These phenolic polymers accumulate in different concentrations, compositions, and localisations within and between cell wall layers and cell types. Lignins were acquired during plant terrestrialisation 450 million years ago, and the diversification of their
Edouard Pesquet +3 more
wiley +1 more source
A randomised controlled clinical study to evaluate the role of Nirvapana Upakrama with Durva ointment in the management of Pittaja Dushta Vrana with special reference to fissure-in-ano [PDF]
Introduction: Fissure-in-ano is an ulcer in the longitudinal axis of lower anal canal. It is having prevalence of about 17.91%. By seeing the signs and symptoms we can consider it as one among the six varieties of Dushta Vrana i.e., Pittaja Dustavrana ...
Dhyan Surendranath +3 more
core +1 more source
Assisted Dying/Assisted Suicide in the UK: An Idea Whose Time Has Come?
ABSTRACT Assisted dying/assisted suicide (AD/AS) has emerged as an important policy issue across the world, with an increasing number of jurisdictions legalizing the practice in recent years. In this context, the article by Bache published earlier this year (2025) in Politics & Policy applied agenda‐setting theory to consider why AD/AS has not been ...
Ian Bache
wiley +1 more source
Pembedahan di dubur lebih mudah melalui inovasi SRAS [PDF]
SERDANG, 6 Feb - Pakar bedah akan boleh memeriksa hujung dubur manusia dan melakukan pembedahan dengan lebih mudah melalui alat yang diberi nama Self Retaining Anal Speculum (SRAS), hasil inovasi yang dibangunkan penyelidik Universiti Putra Malaysia (UPM)
Universiti Putra Malaysia, Pejabat Strategi Korporat dan Komunikasi
core
Tea and Blood–Brain Barrier Homeostasis: Potential Mechanisms and Improvement Strategies
Abstract The blood–brain barrier (BBB), a selective interface regulating cerebral substance exchange, plays a crucial role in maintaining cognitive function and metabolic balance. While tea consumption has been traditionally associated with health benefits, its specific effects on BBB integrity warrant systematic investigation. This review demonstrates
Rongbosen Yue +5 more
wiley +1 more source
مقايسه اثر درمانی مقادير 25 و 50 واحدی سم بوتولينوم در شقاق مزمن مقعدی [PDF]
هدف از اين پژوهش ارزيابی اثرات درمانی مقادير 25 و 50 واحدی سم بوتولينوم در درمان شقاق مزمن مقعد و مقايسه تاثير مقدار دارو در روند بهبودی بيماران بوده است.
اسلامی, شهین +1 more
core
Elucidating Dual Pathways for Light‐Driven Degradation Using Intrinsic Azo Dye Photochemistry
The widespread use of azo dyes in the textile industry and the difficulty in mineralizingthem under environmental conditions makes azo dyes a persistent pollution problem. This work reports the photodegradation of acid violet 3 in which the intrinsic azo dye photochemistry is harnessed to promote degradation. Two photodegradation pathways are proposed:
Domenica R. Fertal +2 more
wiley +1 more source
ABSTRACT Background Chronic constipation is common in India. Identifying its subtypes is essential not only to treat appropriately but also to improve quality of life. Aims To study chronic constipation subtypes and assess their clinical characteristics. Methods This was a prospective observational study.
Ajay Kumar Jain +3 more
wiley +1 more source
Water Stream in Bidet Toilet Commode as a Cause of Anterior Anal Fissure: A Case-Control Study [PDF]
Background: Water used as a single sharp stream in toilet commode for post defecation cleansing is a common practice in several countries across the globe including India. Repeated hitting of the anus by water stream could potentially cause injury to the
Pankaj Garg, Pratiksha Singh
doaj

