Results 121 to 130 of about 393,488 (344)

A Hybrid Diffusion Model Enhances Multiparametric 3D Photoacoustic Computed Tomography

Advanced Science, EarlyView.
The hybrid diffusion PACT (HD‐PACT) system enhances dynamic multiparametric information using only 128–256 ultrasound elements. By overcoming limited‐view artifacts, HD‐PACT refines structural and functional information such as oxygen saturation observed in 3D premium PACT with > 1000 elements. Through cost‐effective and faster multiparametric imaging,
Hyunsu Jeong, Seunghun Oh, Seongwook Choi, Jiwoong Kim, Jinge Yang, Chulhong Kim   +5 more
wiley   +1 more source

Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy

Advanced Science, EarlyView.
Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro, Yoojin Chang, Jeeyoon Kim, Seungjae Lee, Sangyun Na, Cheolhong Park, Hyunhyub Ko   +6 more
wiley   +1 more source

CD169+ Macrophage‐Targeted Immunomodulator to Restore Phagocytic Function and Enhance Antigen Presentation for Lymphatic Metastasis Eradication

Advanced Science, EarlyView.
A CD169+ macrophage‐targeted immunomodulator (G‐LNP@S‐D) is developed to co‐deliver a SHP2 inhibitor and STING agonist, thereby restoring phagocytic function, enhancing antigen presentation by CD169+ macrophages, and promoting T cell priming to eradicate lymphatic metastasis.
Xiayun Chen, Lichong Lu, Yibin Liu, Ziqi Liang, Jianqiao Li, Zhouchuan Shao, Youzhi Tang, Jianhua Zou, Shiying Li, Xiaoyuan Chen   +9 more
wiley   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

Curved Bistable Origami‐Inspired Flexible Transcatheter Mitral Valve Clamping

Advanced Science, EarlyView.
A lightweight bistable curved origami dilator combines reversible deformation and high stability, offering a promising solution for minimally invasive mitral valve repair. Abstract Curved origami exhibits remarkable potential for minimally invasive medical applications owing to its unique geometric programmability and mechanical tunability. Building on
Siyu Gao, Fan Jiang, Xiuting Sun, Peng Qi, Jian Xu   +4 more
wiley   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

Immediate Reconstruction of Pancretaticogastrostomy Following Hepatopancreatoduodenectomy for Biliary Tact Cancer: A Single‐Center Review of 33 Consecutive Patients

Annals of Gastroenterological Surgery, EarlyView.
This study showed that the pancreaticogastrostomy technique in HPD of biliary tract cancer reduced the incidence of pancreatic fistula from 45% to 12%. In‐hospital mortality was also reduced from 27% to 3%. ABSTRACT Background and Purpose Although hepatopancreaticoduodenectomy (HPD) is effective for margin‐negative curative resection of biliary tract ...
Ryusei Matsuyama, Yasuhiro Yabusita, Tomoaki Takahashi, Yutaro Kikuchi, Kouta Sahara, Kentaro Miyake, Yu Sawada, Yuuki Homma, Takafumi Kumamoto, Itaru Endo   +9 more
wiley   +1 more source

Essential Updates 2023/2024: Minimally Invasive Surgery for Biliary Tract Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Minimally invasive surgery (MIS) for biliary tract cancer (BTC) has gained traction with advancements in laparoscopic and robotic techniques. However, its oncological impact remains uncertain. This review highlights key studies from 2023 and 2024 on MIS for BTC, including distal bile duct, hilar bile duct, gallbladder, and intrahepatic bile ...
Osamu Itano, Takuya Minagawa
wiley   +1 more source

Prolonged Prophylactic Antibiotics Based on Preoperative Bile Culture Reduce Surgical Site Infections After Pancreaticoduodenectomy Following Preoperative Biliary Drainage: A Propensity‐Matched Analysis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Objective The optimum duration of prophylactic antibiotics after pancreaticoduodenectomy following preoperative biliary drainage to prevent surgical site infections remains controversial. We evaluate whether a prolonged course of prophylactic antibiotics reduces surgical site infection after pancreaticoduodenectomy following biliary drainage ...
Kyohei Matsumoto, Atsushi Shimizu, Yuji Kitahata, Akihiro Takeuchi, Hideki Motobayashi, Masatoshi Sato, Tomohiro Yoshimura, Shinya Hayami, Atsushi Miyamoto, Manabu Kawai   +9 more
wiley   +1 more source

Gastric Distension Index: A Novel Radiographic Marker Associated With Postoperative Gastric Stasis After Gastrectomy

Annals of Gastroenterological Surgery, EarlyView.
This study introduces the Hiki Index (HI), a novel radiographic metric based on upright abdominal X‐rays, to objectively assess postoperative gastric dilatation after gastrectomy. The HI demonstrated strong predictive value for gastrointestinal symptoms and the need for therapeutic intervention, offering a practical tool for early detection and ...
Hiroki Harada, Yoshiko Yamaoka, Akiko Watanabe, Kota Okuno, Shohei Fujita, Mikiko Sakuraya, Tadashi Higuchi, Koshi Kumagai, Keishi Yamashita, Naoki Hiki   +9 more
wiley   +1 more source