Results 31 to 40 of about 4,191 (133)

The EUROmediCAT Network and Databases: A Resource for Pharmacovigilance in Pregnancy

open access: yesPharmacoepidemiology and Drug Safety, Volume 35, Issue 5, May 2026.
ABSTRACT Background The evidence gap relating to the risk of congenital anomalies (CA) associated with first trimester medication exposure in pregnancy is well recognized. Aims We describe the EUROmediCAT network and databases, and the methodological approach to pregnancy pharmacovigilance.
Helen Dolk   +27 more
wiley   +1 more source

Mucosal Advancement Flap for Fistula-in-ano: A Single-Institution Experience

open access: yesWorld Journal of Colorectal Surgery, 2018
Background and Objective: Mucosal advancement flap (MAF) is a well-described definitive treatment for complex fistula-in-ano, with high healing rates ranging from 37 to 87% for cryptoglandular fistula, but with mild incontinence rates of up to 35%. There
Yui Kaneko   +3 more
doaj   +1 more source

The Ligation of Intersphincteric Fistula Tract Technique: A Preliminary Experience [PDF]

open access: yesAnnals of Coloproctology, 2019
Purpose Surgery is the only treatment for anal fistula. Many surgical techniques have been described. The aim of this study was to communicate the authors’ preliminary experience in the use of a recently proposed, simplified technique. Methods This was a
Pasquale Cianci   +5 more
doaj   +1 more source

Treatment Outcomes of Presacral Pilonidal Sinus Disease Using Crystallised Phenol: A Single‐Centre Clinical Series

open access: yesInternational Wound Journal, Volume 23, Issue 5, May 2026.
ABSTRACT Objective: To evaluate short‐term treatment outcomes and treatment burden in patients with presacral pilonidal sinus disease managed with crystallised phenol in a single‐centre clinical series, with particular emphasis on the relationship between pit burden and session requirement. Methods: Consecutive patients treated with crystallised phenol
Berkan Acar   +4 more
wiley   +1 more source

Outcomes of Pancreas‐Sparing Total Duodenectomy for Severe Duodenal Polyposis in Patients With Familial Adenomatous Polyposis

open access: yesAnnals of Gastroenterological Surgery, Volume 10, Issue 2, Page 534-542, March 2026.
ABSTRACT Aim Spigelman stage IV duodenal polyposis (SP‐stage IV DP) is associated with high duodenal cancer risk in patients with familial adenomatous polyposis (FAP). This study evaluated the surgical and oncological outcomes of pancreas‐sparing total duodenectomy (PSTD) as a surgical prophylaxis for severe duodenal polyposis in FAP.
Takehiro Shiraishi   +8 more
wiley   +1 more source

Recurrent Constellations of Embryonic Malformations (RCEM): Teratogenicity Linked to Transient Hypoxia and Hormone Pregnancy Tests Agrees With RCEM and Suggest a Reactive Oxygen Species Pathogenesis

open access: yesBirth Defects Research, Volume 118, Issue 3, March 2026.
ABSTRACT Background No consistent genetic etiology has been found for a group of six different conditions in humans with multiple malformations called “recurrent constellations of embryonic malformations” (RCEM). Recent studies indicate hypoxia/reoxygenation and generation Reactive Oxygen Species (ROS) as an underlying mechanism for RCEM with the ...
Aaron P. Adam   +3 more
wiley   +1 more source

Pleuroparenchymal Fibroelastosis With a Nodular Shadow Considered To Be Rounded Atelectasis: A Case Report

open access: yesRespirology Case Reports, Volume 14, Issue 3, March 2026.
This report describes the unique clinical course and long‐term survival of two patients with unilateral PPFE who survived for > 10 years. None of the patients had a history of pleurisy or asbestos exposure. One patient had a pleural nodule ipsilateral to the unilateral PPFE lesion, and the other had a pleural nodule contralateral to the PPFE lesion. In
Ayumi Watanabe   +5 more
wiley   +1 more source

Evidence Suggests Prophylactic Antibiotics May Be Unnecessary in Anorectal Surgery—A Systematic Review and Meta‐Analysis

open access: yesWorld Journal of Surgery, Volume 50, Issue 3, Page 587-597, March 2026.
Current evidence does not support the routine use of prophylactic antibiotics in uncomplicated anorectal procedures. However, the certainty of evidence is limited by small sample sizes, methodological heterogeneity, and limited number of available studies. Large‐scale randomized trials are required to strengthen this evidence base.
James Jin   +3 more
wiley   +1 more source

Genetic Diagnoses Among Congenital Anomaly Cases in Europe: Data From the EUROCAT Network

open access: yesPaediatric and Perinatal Epidemiology, Volume 40, Issue 3, Page 414-425, March 2026.
ABSTRACT Background Surveillance of congenital anomaly prevalence over time can identify new teratogens. Anomalies with a genetic cause are excluded from the monitoring. Objectives We examined temporal changes in the proportion of genetic diagnoses among cases with a congenital anomaly.
Jorieke E. H. Bergman   +23 more
wiley   +1 more source

MANAGEMENT OF HIGH FISTULA IN ANO WITH CUTTING SETON

open access: yesGomal Journal of Medical Sciences, 2015
BACKGROUND The aim of this study was to determine the rate of faecal incontinence and recurrence in patients with high fistula in ano treated with Polypropylene (prolene-1) as cutting seton.
Akhtar Munir, Sheikh Qais Falah
doaj  

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