Results 161 to 170 of about 799,230 (312)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Associations of physical fitness with brain structure, pathology and cognition in cognitively normal older adults. [PDF]

NPJ Aging
Schwarck S, Behrenbruch N, Schumann-Werner B, Molloy EN, Garcia-Garcia B, Hochkeppler A, Fischer L, Büchel AT, Incesoy EI, Bernal J, Coello RD, Valdés-Hernández MDC, Wardlaw JM, Vockert N, Müller P, Behnisch G, Morgado B, Esselmann H, Seidenbecher CI, Schott BH, Barthel H, Sabri O, Wiltfang J, Kreissl MC, Düzel E, Maass A.   +25 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Remaining Fit: On the Creation and Maintenance of Fit.

, 2004
This paper serves as the introductory note to the Fifth Workshop on Business Process Modeling, Development, and Support (BPMDS’04). The workshop focuses on the exploration of issues related to the fit between business processes and Business Process Support (BPS) systems.
Regev, Gil, Wegmann, Alain
openaire   +2 more sources

Longitudinal Change and Tracking of Health-Related Physical Fitness in Adolescents Aged 12-16 Years: A Structured Narrative Review. [PDF]

Children (Basel)
Bchini S, Moussaoui D, Tabnjh AK, Bouassida A, Hammami N, Yagin FH.   +5 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Associations Between Health-Related Physical Fitness and Accelerometry-Based Energy Expenditure in Physiotherapy Workers. [PDF]

Physiother Res Int
Horvat Tišlar M, Grozdek Čovčić G, Grubišić M, Jakuš L.   +3 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Association between physical fitness and myopia among school-entry students: a school-based cross-sectional study. [PDF]

Front Public Health
Duan C, Ba Y, Song H, Xue Y.
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source