Results 121 to 130 of about 577,400 (301)

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Evolution and maintenance of a large multidrug-resistant plasmid in a Salmonella enterica Typhimurium host under differing antibiotic selection pressures

mSystems
The dissemination of antibiotic resistance genes (ARGs) through plasmids is a major mechanism for the development of bacterial antimicrobial resistance.
Ming Cheng, Jing-Jing Dai, Jin-Fei Zhang, Yu-Ting Su, Si-Qi Guo, Ruan-Yang Sun, Dong Wang, Jian Sun, Xiao-Ping Liao, Sheng Chen, Liang-Xing Fang   +10 more
doaj   +1 more source

Fitness Costs of Plasmids: a Limit to Plasmid Transmission

Microbiology Spectrum, 2017
ABSTRACT Plasmids mediate the horizontal transmission of genetic information between bacteria, facilitating their adaptation to multiple environmental conditions. An especially important example of the ability of plasmids to catalyze bacterial adaptation and evolution is their instrumental role in the global spread of antibiotic resistance ...
San Millan, A, Maclean, R
openaire   +3 more sources

Hamiltonian model for multidimensional epistasis [PDF]

, 2002
We propose and solve a Hamiltonian model for multidimensional epistastatic interactions between beneficial mutations. The model is able to give rise either to a phase transition between two equilibrium states, without any coexistence, or exhibits a state
AYŞE ERZAN, Bakk A., SEHER ÖZÇELIK, Smith J. M.   +3 more
core   +2 more sources

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

The Mystery of Symbolic Culture: What fitness costs? What fitness benefits?

, 2020
In contrast to language or technology, many “symbolic” cultural phenomena do not seem to confer immediate fitness benefits. Standard approaches to cultural evolution in this domain focus on the recipients or consumers, which does not explain why these phenomena emerge.
Jean-Baptiste André, Nicolas Baumard, Pascal Boyer   +2 more
openaire   +2 more sources

Collembola’s role in regulating mass fluxes in soil and the effects of contrasting life histories [PDF]

, 2006
The study determined metabolic rates and elemental pools for two Collembola species with contrasting life histories. The fittest of the two species, P. minuta, excreted the equivalent of 10–12% of the elemental body content per day, and P.
Hobbie, Erik, Krogh, Paul Henning, Larsen, Thomas, Magid, Jakob, Marc, Ventura   +4 more
core  

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons, Nuria Guillen, Jordi Sarto, Neus Falgàs, Sergi Borrego‐Écija, Diana Esteller‐Gauxax, Magda Castellví, Adrià Tort‐Merino, Agnès Pérez‐Millan, Anna Antonell, Josep M. Augè Fradera, Gerard Piñol, Iolanda Riba, Anna Carnes‐Vendrell, Marta Cullell, Maria Teresa Osuna, Lorena Bajo, Teresa Romero, Eva Bonjoch, Joan Bello, Susana Fernández, Marta Balagué, Isabel Gómez‐Ruiz, Anuncia Boltes, Claustre Pont, Raquel Cuevas, Sara Carrillo, Laura Iglesias, Teresa Maria Casadevall Codina, Lorena Grau Guinea, Fernando Jose Espada, Raquel Sánchez‐Valle, Mircea Balasa, Albert Lladó   +33 more
wiley   +1 more source

Vengefulness Evolves in Small Groups [PDF]

We discuss how small group interactions overcome evolutionary problems that might otherwise erode vengefulness as a preference trait. The basic viability problem is that the fitness benefits of vengeance often do not cover its personal cost.
Daniel Friedman, Nirvikar Singh
core  

Graph-based Framework for Flexible Baseband Function Splitting and Placement in C-RAN

, 2015
The baseband-up centralization architecture of radio access networks (C-RAN) has recently been proposed to support efficient cooperative communications and reduce deployment and operational costs.
Gong, Jie, Liu, Jingchu, Niu, Zhisheng, Xu, Shugong, Zhou, Sheng   +4 more
core   +1 more source