Results 31 to 40 of about 58,890 (262)

Comparison of Two Machine Learning Models for Predicting Volumetric Errors From On-The-Fly R-Test Type Device Data and Virtual End Point Constraints

Journal of Machine Engineering
On-the-fly virtual end-point constraints consists in moving all five axes of the machine tool while nominally maintaining the coincidence of a sensing head centre point with a master ball centre attached to the workpiece table.
Min Zeng, J. R. R. Mayer, Miao Feng, Elie Bitar-Nehme, Xuan Truong Duong   +4 more
doaj   +1 more source

A Method to Optimize Geometric Errors of Machine Tool based on SNR Quality Loss Function and Correlation Analysis

MATEC Web of Conferences, 2017
Instead improving the accuracy of machine tool by increasing the precision of key components level blindly in the production process, the method of combination of SNR quality loss function and machine tool geometric error correlation analysis to optimize
Cai Ligang, Li Jiaying, Cheng Qiang, Sun Bingwei, Wang Yan   +4 more
doaj   +1 more source

Laser R-Test for Angular Positioning Calibration and Compensation of the Five-Axis Machine Tools

Applied Sciences, 2021
The angular positioning error of the rotary stage causes low quality in milling various angles of a workpiece. This study proposes a solution that could improve these issues by using our Laser R-test for angular positioning calibration and compensation ...
Cao-Sang Tran, Tung-Hsien Hsieh, Wen-Yuh Jywe   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Multi-axis synchronous interpolation feed rate adaptive planning with rotational tool center point function under comprehensive constraints

Advances in Mechanical Engineering, 2017
Real-time nonlinear error caused by rotation axis motion in five-axis interpolation can be compensated by rotational tool center point function.
Zhongquan Shi, Wenhua Ye, Ruijun Liang
doaj   +1 more source

Rotation-Angle Solution and Singularity Handling of Five-Axis Machine Tools for Dual NURBS Interpolation

Machines, 2023
Dual NURBS interpolation has been proven an essential technique for high-speed precision machining of complex surfaces. The solution of rotation angles and their derivatives is the basis of kinematic transformation and feedrate optimization in dual NURBS
Pengpeng Sun, Qiang Liu, Jian Wang, Zhenshuo Yin, Liuquan Wang   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A five-axis CNC machining method of orthogonal variable transmission ratio face gear

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2014
In order to verify the validity of the design for the orthogonal variable transmission ratio face gear pair, a five-axis CNC machine tool was used to machine this gear.
Chao LIN, Yu FAN, Yao WANG, Xijun CAO, Zhiqin CAI   +4 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source