Results 61 to 70 of about 45,818 (304)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Tool path design for cube-machining test to minimize influence of Z-axis reversal error motion

Journal of Advanced Mechanical Design, Systems, and Manufacturing
Cube-machining test is a possible method for evaluating the accuracy of five-axis machining centers. Although the geometric errors of rotary axes can be evaluated by measuring the height and inclination errors of the machined surfaces, other error ...
Ryuta SATO, Zongze LI, Shigehiko SAKAMOTO   +2 more
doaj   +1 more source

Machining of wood using a Rip Tooth: effects of work-piece variations on cutting mechanics [PDF]

, 2011
Genetics and environmental conditions during the growth of wood are known to affect the intrinsic characteristics influencing cutting mechanics.
Clahr, Emil, Hackney, Philip, Naylor, Andrew   +2 more
core  

Simulation of a finishing operation : milling of a turbine blade and influence of damping [PDF]

, 2012
Milling is used to create very complex geometries and thin parts, such as turbine blades. Irreversible geometric defects may appear during finishing operations when a high surface quality is expected.
BALMES, Etienne, COFFIGNAL, Gérard, GUSKOV, Mikhail, LORONG, Philippe, TEXIER, Anthony   +4 more
core   +5 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

CUT LAYER IN A MACHINING OF THE CYLINDRICAL GEARS BY THE METHOD OF 5-AXIS ROLL AWAY OF THE END MILL CUTTER ON THE OUTLINE OF THE TOOTH

Technologia i Automatyzacja Montażu, 2021
Gear trains are a key element in the transmission of torque and rotational speed of rotating parts. Technological progress, and five-axis machining in particular, is an interesting and still little-known alternative in the production of this type of ...
Michał Chlost
doaj   +1 more source

Topological model for machining of parts with complex shapes [PDF]

, 2012
Complex shapes are widely used to design products in several industries such as aeronautics, automotive and domestic appliances. Several variations of their curvatures and orientations generate difficulties during their manufacturing or the machining of ...
Bernard, Alain, Mawussi, Kwamiwi, Tapie, Laurent   +2 more
core   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Study on Non-equant Machining of Globoidal Indexing Cam based on Five-axis NC Machine

Jixie chuandong, 2015
Through the analysis of the meshing principle of globoidal indexing cam,combining with the structure characteristics of the five axis NC machine,the cutter location control equation of the equivalent machining of globoidal indexing cam on five-axis NC ...
Fan Youjun, Bie Yu, Li Yang
doaj  

Evaluation of servo, geometric and dynamic error sources on five axis high-speed machine tool

, 2011
Many sources of errors exist in the manufacturing process of complex shapes. Some approximations occur at each step from the design geometry to the machined part.
Andolfatto, Loïc, Lavernhe, Sylvain, Mayer, René   +2 more
core   +2 more sources