Results 21 to 30 of about 686 (227)

Evaluation of dynamic behavior of rotary axis in five-axis machining center (Behavior around motion direction changes)

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2016
Several methods of evaluating the motion accuracy of the rotary axes of five-axis machining centers have been proposed in past studies. Because it is known that particular motion errors exist near motion direction changing points, it is important to ...
Tadahiro NISHIGUCHI, Ryuta SATO, Keiichi SHIRASE   +2 more
doaj   +1 more source

Tool path design for cube-machining test to minimize influence of Z-axis reversal error motion

Journal of Advanced Mechanical Design, Systems, and Manufacturing
Cube-machining test is a possible method for evaluating the accuracy of five-axis machining centers. Although the geometric errors of rotary axes can be evaluated by measuring the height and inclination errors of the machined surfaces, other error ...
Ryuta SATO, Zongze LI, Shigehiko SAKAMOTO   +2 more
doaj   +1 more source

A Comparison Study on the Orientation Capability and Parasitic Motions of Two Novel Articulated Tool Heads with Parallel Kinematics

Advances in Mechanical Engineering, 2013
This paper proposes two novel articulated tool heads based on three degree-of-freedom (DoF) parallel kinematic mechanisms (PKMs). They can realize one translation and the A/B-axis (rotations about the x - and y -axes) linkage movements.
Fugui Xie, Xin-Jun Liu, Tiemin Li
doaj   +1 more source

A Multidimensional Performance Evaluation Method for Blade‑Specialized Five‑Axis Machining Centers

Nanjing Hangkong Hangtian Daxue Xuebao
Machining of aero‑engine blade‑type complex curved‑surface parts places stringent requirements for high accuracy， stability， and efficiency on five‑axis CNC machine tools. To assess the suitability of domestic five‑axis CNC equipment for this application，
LIN Zhiqiang, LU Chengbin, LI Jia, ZHANG Jiacheng, WU Qixun, ZHAO Guolong   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Dual-Motor Position Control Based on a Synchronous State Observer

Machines
High-end vertical five-axis machining centers commonly adopt dual-motor direct-drive configurations for their cradle-type A-axis to improve dynamic performance; however, this approach introduces control challenges in balancing counteracting torque and ...
Li Lei, Qingyang Wang, Yesong Li
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source