Results 191 to 200 of about 1,835,448 (216)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Change in Five-Factor Model Personality Traits During the Acute Phase of the Coronavirus Pandemic

, 2020
Sutin A, Luchetti M, Aschwanden D, Lee JH, Miller AA, Strickhouser JE, STEPHAN Y, Terracciano A.   +7 more
europepmc   +1 more source

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The Hubbard Model: A Computational Perspective

Annual Review of Condensed Matter Physics, 2022
Mingpu Qin, Thomas Schafer, Sabine Andergassen   +2 more
exaly  

Anatomy of sustainable business model innovation

Journal of Cleaner Production, 2020
Feybi Ariani Goni, Jiří Jaromir Klemes, Abbas Mardani   +2 more
exaly  

Model Selection and Model Averaging in Phylogenetics: Advantages of Akaike Information Criterion and Bayesian Approaches Over Likelihood Ratio Tests

Systematic Biology, 2004
Thomas Buckley, Posada D, Jeffrey Thorne   +2 more
exaly  

Bayesian Model Averaging for Linear Regression Models

Journal of the American Statistical Association, 1997
Adrian Raftery, Jennifer A Hoeting, David Madigan   +2 more
exaly