Results 71 to 80 of about 22,958 (200)

TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia [PDF]

, 2018
BACKGROUND: Mutations in the three-prime repair exonuclease 1 (TREX1) gene have been associated with neurological diseases, including Retinal Vasculopathy with Cerebral Leukoencephalopathy (RVCL).
Atkinson, John P, Bertram, Paula, Hajj-Ali, Rula, Jen, Joanna C, Kolar, Grant R, Kothari, Parul H, Schmidt, Robert E   +6 more
core   +1 more source

Haplotype‐resolved genome and pan‐genome graphs reveal the impacts of structural variation on functional genome and feather colors in chickens

iMetaOmics, EarlyView.
This study built a Wenchang chicken haplotype genome and integrated it with 29 others to create a chicken pangenome atlas. Analysis of 354 chickens revealed 185,205 structural variations (SVs), with one‐third derived from homology‐based and transposable elements.
Lihong Gu, Chen Peng, Anhong Chen, Kaiyu Chen, Xinli Zheng, Dongyou Yu, Zhengguang Wang, Lingzhao Fang, George E. Liu, Pengju Zhao   +9 more
wiley   +1 more source

Global Analyses of the Effect of Different Cellular Contexts on MicroRNA Targeting [PDF]

, 2014
MicroRNA (miRNA) regulation clearly impacts animal development, but the extent to which development—with its resulting diversity of cellular contexts—impacts miRNA regulation is unclear.
Abreu-Goodger, Cei, Agarwal, Vikram, Bartel, David, Jan, Calvin H., Jan, Calvin H., Koppstein, David Neal Pira, Nam, Jin-Wu, Rissland, Olivia S., Rissland, Olivia S., Rodriguez, Antony, Yildirim, Muhammed A., Yildirim, Muhammed A.   +11 more
core   +1 more source

ATAC‐seq in Emerging Model Organisms: Challenges and Strategies

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Principle of ATAC‐seq (left), overview of arthropod species with published ATAC‐seq data (middle), summary of experimental design (right). ABSTRACT The Assay for Transposase‐Accessible Chromatin with sequencing (ATAC‐seq) is a versatile and widely utilized method for identifying potential regulatory regions, such as promoters and enhancers, within a ...
Duğçar Ebrar Erdoğan, Shadi Karimifard, Mozhgan Khodadadi, Liucong Ling, Luisa Linke, Ana Catalán, Vincent Doublet, Amanda Glaser‐Schmitt, Oliver Niehuis, Katja Nowick, Antonella Soro, Natascha Turetzek, Barbara Feldmeyer, Nico Posnien   +13 more
wiley   +1 more source

The Dual Role of Exosomes in the Tumor Microenvironment: From Pro‐Tumorigenic Signaling to Immune Modulation

Med Research, EarlyView.
Tumor‐derived exosomes influence proliferation, invasion, angiogenesis, metabolic adaptation, and resistance to therapy. They also shape the immune landscape by modulating antigen presentation, suppressing cytotoxic lymphocyte activity, and promoting the expansion of immunosuppressive cell populations. Although frequently associated with immune evasion,
Jiale Li, Jun Peng, Jiachong Wang, Zigui Chen   +3 more
wiley   +1 more source

Cloning, characterization and immunolocalization of human ameloblastin [PDF]

, 2000
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/93555/1/j.1600-0722.2000.108004303.x ...
Berdal, Ariane, Forest, Nadine, Forsman‐semb, Kristina, Gu, Ting Ting, Krebsbach, Paul H., Kärrman Mårdh, Carina, MacDougall, Mary, Mesbah, Michael, Simmons, Darrin, Yamada, Yoishi   +9 more
core   +1 more source

Identification and characterization of a cucumber accession resistant to tomato leaf curl New Delhi virus

Annals of Applied Biology, EarlyView.
Tomato leaf curl New Delhi virus (ToLCNDV) causes significant yield and fruit quality losses in cucurbit crops, particularly in the Mediterranean region. We identified a new source of resistance to ToLCNDV in cucumber (accession ABS.PE.045) and mapped resistance to four genomic intervals in chromosomes 1, 2, 6, and 7.
Livia Donaire, Cristina Gómez‐Aix, Pau Bretó, Esperanza Gea‐Caballero, Yolanda Hernando, Miguel A. Aranda   +5 more
wiley   +1 more source

Pembentukan Pustaka Genom, Resekuensing, Dan Identifikasi SNP Berdasarkan Sekuen Genom Total Genotipe Kedelai Indonesia [PDF]

, 2015
Resequencing of the soybean genome facilitates SNP marker discoveries useful for supporting the national soybean breedingprograms. The objectives of the present study were to construct soybean genomic libraries, to resequence the whole genome offive ...
Rijzaani, H. (Habib), Satyawan, D. (Dani), Tasma, I. M. (I)   +2 more
core  

Virtual Northern Analysis of the Human Genome [PDF]

, 2007
We applied the Virtual Northern technique to human brain mRNA to systematically measure human mRNA transcript lengths on a genome-wide scale. We used separation by gel electrophoresis followed by hybridization to cDNA microarrays to measure 8,774 mRNA ...
Brown, Patrick O., Donoho, David L., Drori, Iddo, Hurowitz, Evan H., Stodden, Victoria C.   +4 more
core   +3 more sources

Alternative Polyadenylation Contributes to Fibroblast Senescence in Pulmonary Fibrosis

Aging Cell, EarlyView.
In aging or fibrotic fibroblasts, NUDT21 is downregulated, leading to alternative polyadenylation/3′ UTR shortening of STAT3 pathway genes, enhancing their protein expression and promoting STAT3 phosphorylation. Activated STAT3 signaling subsequently drives the expression and release of senescence‐associated secretory phenotype (SASP) factors, thereby ...
Jingjing Huang, Maria Jose Gacha‐Garay, Yu Wang, Scott D. Collum, Rene A. Girard, Hydia Puente, Seung‐Hee Yoo, Rahat Hussain, Jayeshkumar Patel, Manish Patel, Eric J. Wagner, Hari KrishnaYalamanchili, Harry Karmouty‐Quintana, Zheng Chen, Tingting Mills   +14 more
wiley   +1 more source