Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A Word Sense-Oriented User Interface for Interactive Multilingual Text Retrieval [PDF]
, 2011 In this paper we present an interface for supporting a user in an interactive cross-language search process using semantic classes. In order to enable users to access multilingual information, different problems have to be solved: disambiguating and ...
DeLuca, Ernesto William +1 more
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Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Assessing the impact of the five senses on quality of life in mucopolysaccharidoses. [PDF]
Orphanet J Rare Dis, 2020 Giugliani R +3 more
europepmc +1 more source
D-Bees: A Novel Method Inspired by Bee Colony Optimization for Solving Word Sense Disambiguation [PDF]
, 2014 Word sense disambiguation (WSD) is a problem in the field of computational linguistics given as finding the intended sense of a word (or a set of words) when it is activated within a certain context.
Abualhaija, Sallam +1 more
core
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The Proust Machine: What a Public Science Event Tells Us About Autobiographical Memory and the Five Senses. [PDF]
Front Psychol, 2020 Ernst A +4 more
europepmc +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
The Teaching of English Vocabulary through the Multisensory Approach to Older Adults in a Private Nursing Home in Pereira, Colombia [PDF]
, 2019 El siguiente documento es un proyecto de investigación cualitativo cuyo objetivo es integrar la teoría andragógica y el enfoque multisensorial para facilitar el aprendizaje de vocabulario en inglés a adultos mayores.
López Gómez, Luis Felipe +2 more
core