Results 81 to 90 of about 472,647 (332)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The knowing ear : an Australian test of universal claims about the semantic structure of sensory verbs and their extension into the domain of cognition [PDF]

, 1998
In this paper we test previous claims concerning the universality of patterns of polysemy and semantic change in perception verbs. Implicit in such claims are two elements: firstly, that the sharing of two related senses A and B by a given form is cross ...
Evans, Nicholas, Wilkins, David
core  

SensEmbed: Learning sense embeddings for word and relational similarity [PDF]

, 2015
Word embeddings have recently gained considerable popularity for modeling words in different Natural Language Processing (NLP) tasks including semantic similarity measurement.
IACOBACCI, IGNACIO JAVIER, NAVIGLI, ROBERTO, PILEHVAR, MOHAMMED TAHER   +2 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Isolated laryngeal sarcoidosis

Respirology Case Reports, 2020
To improve diagnosis and treatment of laryngeal sarcoidosis, we present a rare case of upper airway obstruction of unclear aetiology, with life‐threatening complication.The patient was a 19‐year boy who presented with progressive severe dyspnoea for ...
Aslan Ahmadi, Fatemeh Dehghani Firouzabadi, Mohammad Dehghani Firouzabadi, Maryam Roomiani   +3 more
doaj   +1 more source

An Experiment on Learning Appropriate Selectional Restrictions from a Parsed Corpus

, 1994
We present a methodology to extract Selectional Restrictions at a variable level of abstraction from phrasally analyzed corpora. The method relays in the use of a wide-coverage noun taxonomy and a statistical measure of the co-occurrence of linguistic ...
Ribas, Francesc
core   +3 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Evaluating ocular torsion following inferior oblique weakening in superior oblique palsy: a pilot study using color fundus photography and spectral domain optical coherence tomography

BMC Ophthalmology
Purpose To compare spectral domain optical coherence tomography (OCT) and color fundus photography (CFP) for assessing ocular cyclotorsion in unilateral congenital superior oblique palsy (SOP) before and after inferior oblique disinsertion.
Kaveh Abri Aghdam, Afsane Katiraee, Samira Chaibakhsh, Mostafa Soltan Sanjari, Arezoo Miraftabi, Fateme Nadjafi, Ali Sadeghi, Vahid Zare Hosseinabadi, Amin Zand   +8 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source