Results 201 to 210 of about 20,193 (282)

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Untreated Hair Dye Effluents Enter the Environment: Are They a Threat to Human Health?

Environmental Toxicology, EarlyView.
ABSTRACT The effluents generated during the process of hair dyeing exhibit a complex composition, comprising chemical compounds with varying toxicity levels. While the adverse impact of hair dyes on human health is acknowledged, there is a notable absence of studies addressing the toxicity associated with effluents produced during these activities. The
Letícia Cristina Gonçalves, Matheus Mantuanelli Roberto, Adriana Fabiana Corrêa da Silva, Maria Aparecida Marin‐Morales   +3 more
wiley   +1 more source

Unraveling the complexity of PD-L1 assays: a descriptive review of the methodology, scoring, and practical implications. [PDF]

Front Oncol
Vainer GW, Badve SS, Rajadurai P, Soares FA, Viale G, Büttner R, Nuti S, Juco J, Krishnan R, Tsao MS.   +9 more
europepmc   +1 more source

Inhibition of PHF1 promotes ferroptosis via IRES‐dependent Snail translation regulation in pancreatic ductal adenocarcinoma

VIEW, EarlyView.
PHF1 is a known epigenetic regulator involved in transcriptional silencing in cancer. In this study, we identified PHF1 as an oncogene that promotes PDAC progression and demonstrated that its inhibition induces ferroptosis. Mechanistically, PHF1 physically interacts with the FBL/NOP56/NOP58 snoRNP complex to enhance the IRES‐dependent translation of ...
Yujiao Xie, Shan Jin, Yao Zhan, Tiantian Du, Yaqi Dong, Peilong Li, Xiaoshi Zhang, Qiuchen Qi, Jie Gao, Chuanxin Wang   +9 more
wiley   +1 more source

The effect of chemical fixation with paraformaldehyde, glutardialdehyde or methanol on immunofluorescence staining of neutrophils and neutrophil extracellular traps. [PDF]

Innate Immun
Pilchová V, Richter A, Meurer M, Schulz C, von Köckritz-Blickwede M.   +4 more
europepmc   +1 more source

Candidozyma cisalpinoae sp. nov., a Genomically Distinct, Flower‐Associated Yeast, Resistant to Azoles and Exhibiting Pathogenicity‐Related Traits

Yeast, EarlyView.
Candidozyma cisalpinoae sp. nov. represents a distinct species within the Candidozyma clade, supported by multilocus phylogeny, genome‐scale metrics, and phenotypic traits. Although isolated from floral substrates, this species displays several traits commonly associated with opportunistic pathogenic yeasts.
Anna Paula O. Tironi, Katharina O. Barros, Luiz Felipe A. Santana, Daniela L. Souza, Ana Raquel O. Santos, Giovana R. Ávila, Thiago M. Batista, Glória R. Franco, Raphael S. Pimenta, Paula B. Morais, Marc‐André Lachance, Carlos A. Rosa, Susana Johann   +12 more
wiley   +1 more source

Effects of fixation and demineralization on histomorphology and DNA amplification of canine bone marrow. [PDF]

Vet Pathol
Diamantino GML, Beeler-Marfisi J, Foster RA, Sears W, Defarges A, Vernau W, Bienzle D.   +6 more
europepmc   +1 more source

Sperm Transfer Under Behavioral and Morphological Constraints in the Orb‐Web Spider Genus Argiope

Integrative Zoology, EarlyView.
The polygamous mating system of the orb‐web spider genus Argiope provides a model to study the evolution of sperm transfer under morphological and behavioral constraints. This helps us to understand how male and female behavioral and morphological reproductive traits influence sperm transfer.
Chathuranga Dharmarathne, Donald J. McLean, Peter Michalik, M. E. Herberstein   +3 more
wiley   +1 more source

New dimensions in acidocalcisome research: the potential of cryo-EM to uncover novel aspects of protozoan parasite physiology. [PDF]

mBio
Augusto I, Lemos M, Girard-Dias W, Oliveira Filho JdA, Pascutti PG, de Souza W, Miranda K.   +6 more
europepmc   +1 more source

Extraocular Photoreception in Optic Lobes, Suckers, and Skin of Octopus vulgaris

Integrative Zoology, EarlyView.
Evidence of extra‐ocular photoreception in Octopus vulgaris (a) Diagram of the O. vulgaris different tissues considered: SPB, sucker proximal big; SPL, sucker proximal large; SM, sucker medium; SD, sucker distal; SK, skin; OL, optic lobes; RT, retina; (b‐d) Gene expression analysis of Ov‐GRK1 (red), Ov‐retinochrome (green), Ov‐rhodopsin (blue) mRNA ...
Valeria Maselli, Al‐Sayed Al‐Soudy, Mariangela Norcia, Stefania Galdiero, Sara Palladino, Emanuela Cirillo, Gianluca Polese, Anna Di Cosmo   +7 more
wiley   +1 more source