Results 71 to 80 of about 11,465 (303)

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Evaluation and Comparative Analysis of Newer Compound Fixatives [PDF]

, 2017
BACKGROUND : Fixation is the crucial step in the practice of diagnostic pathology. Formalin has been used as a general fixative for more than one century.
Muthuselvi, S
core  

Fixed Stars That Are Not Fixed [PDF]

Scientific American, 1921
n ...
openaire   +2 more sources

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source

Identification of a reliable fixative solution to preserve the complex architecture of bacterial biofilms for scanning electron microscopy evaluation.

PLoS ONE, 2020
Bacterial biofilms are organized sessile communities of bacteria enclosed in extracellular polymeric substances (EPS). To analyze organization of bacteria and EPS in high resolution and high magnification by scanning electron microscopy (SEM), it is ...
Rohana P Dassanayake, Shollie M Falkenberg, Judith A Stasko, Adrienne L Shircliff, John D Lippolis, Robert E Briggs   +5 more
doaj   +1 more source

A cold bath for a formalin-free laboratory: alternative fixative methods in early developmental stages of the sea urchin Paracentrotus lividus (Lamarck, 1816)

Invertebrate Survival Journal, 2021
Fixatives are widespread in biological and medical research because they allow preserving specimens for a long time. Historically, formaldehyde has been the most used fixative so far, but new solutions are needed because of its carcinogenicity.
A Cannavacciuolo, A Chiarore, M Munari
doaj   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

The Impact of Tissue Fixatives on Morphology and Antibody-based Protein Profiling in Tissues and Cells [PDF]

, 2010
Pathology archives harbor large amounts of formalin-fixed, paraffin-embedded tissue samples, used mainly in clinical diagnostics but also for research purposes.
Paavilainen, Linda, Wester, Kenneth,, Edvinsson, Åsa,, Paavilainen, Linda,, Kampf, Caroline,, Pontén, Fredrik, Pontén, Fredrik,, Kampf, Caroline, Hober, Sophia,, Asplund, Anna,, Edvinsson, Åsa, Asplund, Anna, Wester, Kenneth   +12 more
core   +1 more source

To Fix or Not to Fix, the Fix: Reassessing the Effectiveness of the 4pm Fix. A Pre-Registered Study

Pacific-Basin Finance Journal
This study critically re-evaluates the effectiveness of the WM/Refinitiv (WMR) methodology for Foreign Exchange (FX) benchmark rates following its revision in 2015. Through the use of proprietary high-frequency trading data provided by Refinitiv, the research assesses the representativeness, attainability, and robustness of the WMR 4 pm fix.
Benenchia, Matteo, Galati, Luca, Lepone, Andrew   +2 more
openaire   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source