Results 191 to 200 of about 42,360 (298)

Temporal Modeling of Amyloid and Tau Trajectories in Alzheimer's Disease Using PET and Plasma Biomarkers

open access: yesAnnals of Neurology, EarlyView.
Objective This study aimed to compare positron emission tomography (PET) and plasma‐based temporal modeling of amyloid and tau biomarkers in Alzheimer's disease. Methods Longitudinal amyloid PET (n = 1,097, mean age ± SD = 72.5 ± 7.38 year, 51.4% male), 18F‐flortaucipir tau‐PET (n = 230, 74.3 ± 7.18 year, 52.2% female), and Fujirebio Lumipulse plasma p‐
Christopher A. Brown   +14 more
wiley   +1 more source

Leveraging Two-Stage δ Global Sensibility Analysis Method to Inform Parameter Estimation in PBPK Models. [PDF]

open access: yesPharm Stat
Cuquerella-Gilabert M   +7 more
europepmc   +1 more source

Finding Small Weight Isomorphisms with Additional Constraints is Fixed-Parameter Tractable [PDF]

open access: green, 2017
V. Arvind   +3 more
openalex   +1 more source

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

open access: yesAngewandte Chemie International Edition, EarlyView.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne   +22 more
wiley   +1 more source

From Gap-Exponential Time Hypothesis to Fixed Parameter Tractable Inapproximability: Clique, Dominating Set, and More

open access: green, 2020
Parinya Chalermsook   +6 more
openalex   +2 more sources

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