Results 71 to 80 of about 10,928,752 (312)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

An inertial parallel algorithm for a finite family of G-nonexpansive mappings with application to the diffusion problem

Advances in Difference Equations, 2021
For finding a common fixed point of a finite family of G-nonexpansive mappings, we implement a new parallel algorithm based on the Ishikawa iteration process with the inertial technique. We obtain the weak convergence theorem of this algorithm in Hilbert
Phakdi Charoensawan, Damrongsak Yambangwai, Watcharaporn Cholamjiak, Raweerote Suparatulatorn   +3 more
doaj   +1 more source

An Extragradient Method for Fixed Point Problems and Variational Inequality Problems [PDF]

Journal of Inequalities and Applications, 2007
An extragradient method is presented for the fixed point problems and variational inequality problems. A common element of the set of fixed points of a nonexpansive mapping and the set of solutions of the variational inequality for a monotone mapping is found using the considered method.
Yonghong Yao, Jen-Chih Yao, Yeong-Cheng Liou   +2 more
openaire   +3 more sources

The structure of fixed-point sets of Lipschitzian type semigroups [PDF]

, 2012
The purpose of this paper is to establish some results on the structure of fixed point sets for one-parameter semigroups of nonlinear mappings which are not necessarily Lipschitzian in Banach spaces.
DR Sahu, Sahu, DR, Donal O’Regan, RP Agarwal, O’Regan, Donal, Agarwal, RP   +5 more
core   +1 more source

Fixed point theorems in the study of operator equations in ordered Banach spaces and their applications

, 2021
We use fixed point index properties and the general minorant principle (see Theorem 7.B in [12]) to prove new fixed point theorems for operators leaving invariant a cone in a Banach space. Main ideas of this work are inspired from the work in [11].
Mechrouk, Salima
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Some aspect of perturbed extended general quasi variational inequality by using auxiliary principle technique

Journal of Taibah University for Science, 2020
Perturb Extended GQVI provide natural, unified, simple and novel context to study an extensive class of equilibrium problems arising in various fields. In this work, we familiarize and study a number of new and known computational approaches to solve new
Ziyad Ali Alhussain
doaj   +1 more source

On solutions of inclusion problems and fixed point problems [PDF]

Fixed Point Theory and Applications, 2013
The paper proposes an iterative algorithm for the solution of the following problem: \[ x= S(x) \text{ and } x\in (A+B)^{-1}(0), \] where \(S:C\to C\) is a mapping and \(A,B:C\to H\) are two monotone mappings on a nonempty, closed, convex subset \(C\) of an Hilbert space \(H\).
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source