Results 61 to 70 of about 2,017,440 (319)

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Some examples for the fixed point property [PDF]

open access: yesPacific Journal of Mathematics, 1971
Examples are given of polyhedra K and L which have the homotopy invariant fixed point property, in the sense that all polyhedra of the same homotopy type have the fixed point property (in fact K and L have no self-maps of zero Lefschetz number) but for which K X L fails to have the fixed point property.
openaire   +3 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Decompositions and the fixed point property for multifunctions

open access: yesLe Matematiche, 1997
Relations between the fixed point properties for some classes of multifunctions of a compact Hausdorff space X, of a decomposition space X/D, where D is an upper semi-continuous decomposition of X, and of the members of D are studied. Results are applied
Janusz J. Charatonik
doaj  

Property ( k) of Orlicz Sequence Spaces

open access: yesJournal of Harbin University of Science and Technology, 2017
Property ( k) is an important geometric property in Banach spaces,and it is closely associated with fixed point property. By the geometric theory of Banach spaces and Orlicz spaces, we investigated the characterization for property( k) in a special ...
ZUO Ming-xia, PENG Li-na
doaj   +1 more source

Fixed point theorems for Boolean networks expressed in terms of forbidden subnetworks [PDF]

open access: yes, 2014
We are interested in fixed points in Boolean networks, {\em i.e.} functions $f$ from $\{0,1\}^n$ to itself. We define the subnetworks of $f$ as the restrictions of $f$ to the subcubes of $\{0,1\}^n$, and we characterizes a class $\mathcal{F}$ of Boolean ...
Richard, Adrien
core   +2 more sources

Sequences Having an Effective Fixed-Point Property [PDF]

open access: yesTransactions of the American Mathematical Society, 1972
Let a be any function whose domain is the set N of all natural numbers. A subset B of Nprecompletes the sequence a if and only if for every partial recursive function (p.r.f.) b there is a recursive function f such that af extends ao and f [N-Dom 0] ebB. An object e in the range of a completes a if and only if a -I[{e}] precompletes a.
openaire   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

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