Results 101 to 110 of about 3,050,013 (267)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Assessment of different materials used for fabrication of fixed free fixed dental prostheses: finite element analysis

Bulletin of the National Research Centre
Background This research assessed three materials to be used in the fabrication of fixed free fixed dental prosthesis using finite element analysis. Total deformation, Von Mises stress maximum amounts and sites on both the bone, and the fixed dental ...
Rami M. Galal, Menatallah M. ElHotieby, Ghada E. Hamza, Yosra M. Eldemery   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Fracture strength and failure patterns of different restoration approaches in endodontically treated maxillary premolars: an in vitro study with fractographic analysis

BMC Oral Health
Background The restoration of endodontically treated premolars has been a controversial topic. Whether a post or a more conservative option should be used remains inconclusive.
Amira Yehia Amin, Amina Hamdy, Marwa Wahsh, Amr El Etreby, Marwa Emam   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Trueness and depth discrepancy of post-space scans using an intraoral scanner: influence of preparation dimensions: an in vitro study

BMC Oral Health
Background Intraoral scanning of post spaces offers a potential alternative to conventional impressions, but its effectiveness depends on overcoming limitations influenced by post space dimensions.
Mostafa Shahin Zaki, Cherif Adel Mohsen, Mostafa Elhusseiny Mohamed   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Effect of in-office bleaching on surface roughness of additively versus subtractively manufactured tooth-colored materials used for fixed definitive prostheses

BMC Oral Health
Background In-office dental bleaching is recognized as a conservative and effective approach for achieving tooth whitening. Although previous studies have investigated additively manufactured composite resins, there is limited knowledge in terms of the ...
Zahraa Hassan Ali Sharshar, Waleed Elshahawy, Dina Mohamed Elshokafy   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source