Results 161 to 170 of about 3,736,885 (316)

Fixed Orthopaedic Appliances

, 2020
For successful therapy of one of the most common disorders amongst those patients presenting with malocclusions, class II malocclusion must be correctly diagnosed prior to any therapy being undertaken, to ensure the best possible course of treatment. The
Sanalla, Anas Abulkasim
core  

Comparative impact of clear aligners versus fixed orthodontic appliances on periodontal health, pain, and quality of life: a systematic review and meta-analysis. [PDF]

BDJ Open
Kaur K, Quadri SA, Saini RS, Alarcón-Sánchez MA, Heboyan A.   +4 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Short And Constructive Proof of Tarski's Fixed-Point Theorem [PDF]

I give short and constructive proofs of Tarski's fixed-point theorem, and of a much-used extension of Tarski's fixed-point theorem to set- valued maps.tarski, fixed-point theorem, supermodular, supermodular games, strategic complementarities, equilibrium
Federico Echenique
core  

Comparative evaluation of apical root resorption in adult patients treated with clear aligners and fixed orthodontic appliances using CBCT. [PDF]

Acta Odontol Scand
Issrani R, Alshammari AH, Alrwuili MR, Aljabab MA, Alenzi NA, Joshi P, Aldoseri YT.   +6 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Semiparametric Fixed-Effects Estimator [PDF]

This paper describes the Stata implementation of Baltagi and Li's (2002) series estimator of partially linear panel data models with fixed effects. After a brief description of the estimator itself, we describe the new command xtsemipar. We then simulate
Fran�ois Libois, Vincenzo Verardi
core  

Seedling-Stage Responses of <i>Lumnitzera littorea</i> to Substrate Type and Salinity-Structured Irrigation Regimes in Can Gio, Vietnam. [PDF]

Plants (Basel)
Huynh DH, Bui-Nguyen TK, Dang NH, Nguyen TP, Luong TT, Tran HD.   +5 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source