Results 251 to 260 of about 12,179,068 (306)

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Broken or Fixed Effects? [PDF]

open access: possibleJournal of Econometric Methods, 2018
Abstract We replicate eight influential papers to provide empirical evidence that, in the presence of heterogeneous treatment effects, OLS with fixed effects (FE) is generally not a consistent estimator of the average treatment effect (ATE).
Charles E. Gibbons   +2 more
openaire   +1 more source

Fixed-effect Versus Random-effects Models for Meta-analyses: Fixed-effect Models

European Urology Focus, 2023
A fixed-effect model considers a common underlying effect size for all the studies included in a meta-analysis. In the face of appreciable between-study heterogeneity, a fixed-effect model is a valuable tool when precision is the priority.
Hadi Mostafaei   +2 more
openaire   +2 more sources

Fixed- and Random-Effects Models

2021
Deciding whether to use a fixed-effect model or a random-effects model is a primary decision an analyst must make when combining the results from multiple studies through meta-analysis. Both modeling approaches estimate a single effect size of interest.
openaire   +2 more sources

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