Results 61 to 70 of about 1,431,709 (308)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Relationships between exchange rate regime, real exchange rate volatility and currency structure of government bonds in emerging markets

open access: yesReview of Economic Perspectives, 2020
Public foreign currency borrowing is a common problem of emerging markets. Scholars named it the original sin of foreign debt. It has a proven negative influence on economic growth and development, undermining financial stability, and increasing the ...
Dudzich Viktar
doaj   +1 more source

(WP 2013-06) The Impact of Output and Exchange Rate Volatility on Fixed Private Investment: Evidence from Selected G7 Countries [PDF]

open access: yes, 2013
This study examines the impact of shocks to exchange rate and output uncertainty (volatility) on real private fixed investment (FI) in Canada, Germany, the United Kingdom, and the United States.
Chowdhury, Abdur, Wheeler, Mark
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

THE CURRENT ACCOUNT DEFICIT AND THE FIXED EXCHANGE RATE. ADJUSTING MECHANISMS AND MODELS. [PDF]

open access: yesAnnals of the University of Oradea: Economic Science, 2010
The main purpose of the paper is to explain what measures can be taken in order to fix the trade deficit, and the pressure that is upon a country by imposing such measures.
HATEGAN D.B. Anca, NEGREA Adrian
doaj  

The macroeconomic implication of exchange rate regimes [PDF]

open access: yes
This study investigates the relation between macroeconomic variables such as real GDP growth, inflation, unemployment rate, trade deficit and the exchange regimes.
Cane, Koteski   +2 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Central bank credibility and the sustainability of exchange rate regimes in Vietnam

open access: yesJournal of International Economics and Management, 2018
This paper deals with the central bank credibility to sustain exchange rate regimes in inflation control. We find that the central bank credibility relates to the ability the central bank to build a credible monetary policy to control inflation under the
Thu Hien Mai
doaj  

The exchange rate control - Hungarian experiences

open access: yesEkonomia i Prawo, 2009
Since the 1990s various kinds of exchange rate regimes have been employed, such as the adjustable peg regime, the crawling peg regime and the so-called ERM II shadow.
Dorota Zbierzchowska
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

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