Results 351 to 360 of about 11,744,847 (379)

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

On fixed point theorem

Proceedings of the Japan Academy, Series A, Mathematical Sciences, 1974
openaire   +3 more sources

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Fixed-Point Back-Propagation Training

Computer Vision and Pattern Recognition, 2020
Recent emerged quantization technique (i.e., using low bit-width fixed-point data instead of high bit-width floating-point data) has been applied to inference of deep neural networks for fast and efficient execution.
Xishan Zhang, Shaoli Liu, Rui Zhang, Chang Liu, Di Huang, Shiyi Zhou, Jiaming Guo, Qi Guo, Zidong Du, Tian Zhi, Yunji Chen   +10 more
semanticscholar   +1 more source

Fixed points vs. coupled fixed points

Journal of Fixed Point Theory and Applications, 2018
In this paper, we will show some connections between fixed point and coupled fixed point problems in Banach and metric spaces.
openaire   +2 more sources

A Fast Fixed-Point Algorithm for Independent Component Analysis of Complex Valued Signals

International Journal of Neural Systems, 2000
Separation of complex valued signals is a frequently arising problem in signal processing. For example, separation of convolutively mixed source signals involves computations on complex valued signals.
Ella Bingham, Aapo Hyvärinen
semanticscholar   +1 more source

Counting Fixed Points

Proceedings of the American Mathematical Society, 1982
In this paper, we develop a machine which enables us to predict, in many cases, the exact number of fixed points of a local diffeomorphism. Though much more general, our technique applies in particular to locally expansive maps on compact, connected, orientable differentiable manifolds.
openaire   +2 more sources

Fixed-Point Mathematics

2013
Many embedded systems applications need to perform floating-point calculations. As mentioned in the previous chapter, however, small-scale microcontrollers may not have hardware support for floating-point calculations with a floating-point unit (FPU).
openaire   +2 more sources