Results 81 to 90 of about 1,628,955 (269)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Generalized (ψ,α,β)—Weak Contractions for Initial Value Problems
Mathematics, 2019 A class of generalized ( ψ , α , β ) —weak contraction is introduced and some fixed-point theorems in a framework of partially ordered metric spaces are proved.
Piyachat Borisut +3 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Abstract Fixed-Point Theorems and Fixed-Point Iterative Schemes
Symmetry, 2022 Mathematical methods are extensively used in dealing with simulation and approximation problems related to computer science, engineering, physics, and many others [...]
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Discontinuity and Fixed Points
Journal of Mathematical Analysis and Applications, 1999 The author gives a fixed point theorem for a self-map of a metric space \((X,d)\) under a contractivity condition which does not force the map to be continuous at the fixed point. He also gives a common fixed point theorem for two self-mappings \(f,g\) which satisfy a contractivity condition and moreover are ``weakly commuting'', i.e. there exists some
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
On Characterizations of Fixed and Common Fixed Points
Journal of Mathematical Analysis and Applications, 1998 The authors introduce the concept of \(L\)-mapping which is equivalent to the concept of \(C\)-mapping introduced by \textit{S. Zhang} [Proc. Am. Math. Soc. 97, 343-346 (1986; Zbl 0593.54045)] and establish criteria for the existence of fixed points of \(L\)-mappings.
Liu, Zeqing, Xu, Yuguang, Cho, Yeol Je
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