Results 231 to 240 of about 2,962,665 (347)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

A Globalized Inexact Semismooth Newton Method for Nonsmooth Fixed-point Equations involving Variational Inequalities [PDF]

open access: green
Amal Alphonse   +3 more
openalex   +1 more source

An Open-Source, Low-Cost Solution for 3D Scanning. [PDF]

open access: yesSensors (Basel)
Mateescu A   +3 more
europepmc   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Hyers-Ulam Stability of N-Dimensional Additive Functional Equation in Modular Spaces Using Fixed Point Method

open access: gold
Gowri Senthil   +5 more
openalex   +2 more sources

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